Azido-PEG7-COOtBu manufacturers
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| | Azido-PEG7-COOtBu Basic information |
| Product Name: | Azido-PEG7-COOtBu | | Synonyms: | Azido-PEG7-COOtBu;Azido-PEG7-tBu Ester;N3-PEG7-COOtBu;4,7,10,13,16,19,22-Heptaoxatetracosanoic acid, 24-azido-, 1,1-dimethylethyl ester;N3-PEG7-CH2CH2COOtBu;tert-butyl 1-azido-3,6,9,12,15,18,21-heptaoxatetracosan-24-oate | | CAS: | 2596867-40-0 | | MF: | | | MW: | 479.57 | | EINECS: | | | Product Categories: | | | Mol File: | 2596867-40-0.mol |  |
| | Azido-PEG7-COOtBu Chemical Properties |
| | Azido-PEG7-COOtBu Usage And Synthesis |
| Uses | Azido-PEG7-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG7-t-butyl ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | Biological Activity | Azido-PEG7-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | IC 50 | PEGs | | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| | Azido-PEG7-COOtBu Preparation Products And Raw materials |
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