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| | K-Ras ligand-Linker Conjugate 3 Basic information |
| Product Name: | K-Ras ligand-Linker Conjugate 3 | | Synonyms: | K-Ras ligand-Linker Conjugate 3;1-Piperazinecarboxylic acid, 2-(cyanomethyl)-4-[5,6,7,8-tetrahydro-2-[[(2S,4R)-1-methyl-4-[2-[2-[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]-2-pyrrolidinyl]methoxy]-7-(1-naphthalenyl)pyrido[3,4-d]pyrimidin-4-yl]-, 1,1-dimethylethyl ester, (2S)- | | CAS: | 2378261-87-9 | | MF: | C49H65N7O10S | | MW: | 944.15 | | EINECS: | | | Product Categories: | | | Mol File: | 2378261-87-9.mol |  |
| | K-Ras ligand-Linker Conjugate 3 Chemical Properties |
| Boiling point | 1014.8±75.0 °C(Predicted) | | density | 1.32±0.1 g/cm3(Predicted) | | pka | 7.98±0.60(Predicted) | | form | Solid | | color | Off-white to light yellow |
| | K-Ras ligand-Linker Conjugate 3 Usage And Synthesis |
| Uses | K-Ras ligand-Linker Conjugate 3 (Compound 001371) incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 3 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1]. | | References | [1] Andrew P. Crew, et al. Modulators of proteolysis and associated methods of use. WO2019195609A2. |
| | K-Ras ligand-Linker Conjugate 3 Preparation Products And Raw materials |
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