VH 032-linker 1 manufacturers
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| | VH 032-linker 1 Basic information |
| Product Name: | VH 032-linker 1 | | Synonyms: | VH 032-linker 1;VH 032 amide-PEG3-amine;VH 032 amide-PEG3-amine dihydrochloride;(S,R,S)-AHPC-PEG3-NH2 (dihydrochloride);(2S,4R)-1-[(S)-14-Amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecan-1-oyl]-4-hydroxy-N-[4-(4-methylthiazol-5-yl)benzyl]pyrrolidine-2-carboxamide Dihydrochloride(contains <6%H2O) | | CAS: | 2376990-24-6 | | MF: | C30H46ClN5O7S | | MW: | 656.24 | | EINECS: | | | Product Categories: | | | Mol File: | 2376990-24-6.mol |  |
| | VH 032-linker 1 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO |
| | VH 032-linker 1 Usage And Synthesis |
| Uses | (S,R,S)-AHPC-PEG3-NH2 dihydrochloride (VH032-PEG3-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology[1] | | storage | Store at -20°C | | References | [1] Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Med Chem. 2018 Jan 25;61(2):504-513. DOI:10.1021/acs.jmedchem.6b01912
[2] Salami J, et al. Waste disposal-An attractive strategy for cancer therapy. Science. 2017;355(6330):1163-1167. DOI:10.1126/science.aam7340 |
| | VH 032-linker 1 Preparation Products And Raw materials |
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