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Sigma-Aldrich |
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E3 ligase Ligand-Linker Conjugates 7 manufacturers
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| | E3 ligase Ligand-Linker Conjugates 7 Basic information |
| Product Name: | E3 ligase Ligand-Linker Conjugates 7 | | Synonyms: | E3 ligase Ligand-Linker Conjugates 7;(2S,4R)-1-((S)-17-amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride;VH 032 Linker 2;VH032-PEG4-NH2 hydrochloride;VHL Ligand-Linker Conjugates 4 hydrochloride;VH03-linker;(S,R,S)-AHPC-PEG4-NH2 hydrochloride (VHL Ligand-Linker Conjugates 4 hydrochloride;(2S,4R)-1-((S)-17-amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride | | CAS: | 2064292-52-8 | | MF: | C32H50ClN5O8S | | MW: | 700.29 | | EINECS: | | | Product Categories: | | | Mol File: | 2064292-52-8.mol |  |
| | E3 ligase Ligand-Linker Conjugates 7 Chemical Properties |
| storage temp. | 2-8°C, sealed storage, away from moisture | | solubility | DMF: 1.1 mg/ml; DMSO: 1.1 mg/ml; Ethanol: 0.7 mg/ml; PBS (pH 7.2): 5 mg/ml | | form | A crystalline solid | | color | White to yellow |
| | E3 ligase Ligand-Linker Conjugates 7 Usage And Synthesis |
| Uses | (S,R,S)-AHPC-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. | | IC 50 | VHL | | References | [1] Crew, Andrew P, et al. MDM2-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. US20170008904A1. |
| | E3 ligase Ligand-Linker Conjugates 7 Preparation Products And Raw materials |
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