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| Product Name: | BZAD01 | | Synonyms: | BZAD01;Inhibitor,NR2B,NMDA,iGluR,BZAD01,Ionotropic glutamate receptors,inhibit;Benzenecarboximidamide, 4-(trifluoromethoxy)-N-[[2-(trifluoromethyl)phenyl]methyl]-;4-(trifluoromethoxy)-N-(2-(trifluoromethyl)benzyl)benzimidamide;BZAD01, 10 mM in DMSO;CHEMBL159279;4-(Trifluoromethoxy)-N-(2-(trifluoromethyl)benzyl)benzimidamide , BZAD-01 | | CAS: | 305339-41-7 | | MF: | C16H12F6N2O | | MW: | 362.27 | | EINECS: | | | Product Categories: | | | Mol File: | 305339-41-7.mol |  |
| | BZAD01 Chemical Properties |
| Boiling point | 340.8±52.0 °C(Predicted) | | density | 1.34±0.1 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | Methanol : 250 mg/mL (690.09 mM; Need ultrasonic)|DMSO : 100 mg/mL (276.04 mM; Need ultrasonic) | | pka | 9.56±0.50(Predicted) | | form | Solid | | color | White to off-white |
| | BZAD01 Usage And Synthesis |
| Uses | BZAD-01 is a potent, selective and orally active inhibitor of NMDA NR2B subunit, with a Ki of 72 nM. BZAD-01 can improve postural asymmetry as well as Apomorphine-induced rotation[1]. | | Biological Activity | BZAD-01 is a potent, selective and orally active inhibitor of NMDA NR2B subunit, with a Ki of 72 nM. BZAD-01 can improve postural asymmetry as well as Apomorphine-induced rotation[1]. | | References | [1]. Truong L, et, al. Behavioural effects of a selective NMDA NR1A/2B receptor antagonist in rats with unilateral 6-OHDA+parafascicular lesions. Brain Res Bull. 2009 Feb 16;78(2-3):91-6. |
| | BZAD01 Preparation Products And Raw materials |
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