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S-Methyl-L-thiocitrulline manufacturers
- S-MTC
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- $1980.00
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2026-07-27
- CAS:156719-41-4
- Purity:
- Supply Ability: 10g
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| | S-Methyl-L-thiocitrulline Basic information |
| Product Name: | S-Methyl-L-thiocitrulline | | Synonyms: | S-METHYL-L-THIOCITRULLINE ACETATE;H-THIOCIT(S-ME)-OH ACOH;s-methylthiocitrulline;L-Thiocitrulline2HCl;(2S)-2-amino-5-[[amino(methylsulfanyl)methylidene]amino]pentanoic acid;(2S)-2-amino-5-[[amino-(methylthio)methylene]amino]valeric acid;(2S)-2-azanyl-5-[[azanyl(methylsulfanyl)methylidene]amino]pentanoic acid;S-Me-TC, SMTC | | CAS: | 156719-41-4 | | MF: | C7H15N3O2S | | MW: | 205.28 | | EINECS: | | | Product Categories: | | | Mol File: | 156719-41-4.mol |  |
| | S-Methyl-L-thiocitrulline Chemical Properties |
| Boiling point | 369.4±52.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | storage temp. | Store at 0°C | | solubility | Soluble in DMSO | | pka | 2.48±0.24(Predicted) |
| | S-Methyl-L-thiocitrulline Usage And Synthesis |
| Uses | S-MTC is a selective type I nitric oxide synthase (NOS) inhibitor. | | Definition | ChEBI: An L-arginine derivative in which the guanidino NH2 group of L-arginine is replaced by a methylsufanyl group. | | in vivo | S-MTC (S-methyl-L-thiocitrulline) is a selective neuronal NOS-inhibitor. Following pretreatment with S-MTC (i.c.v.), the HBO2-induced antinociception is significantly antagonized. In Experiment #2, different groups of mice are pretreated with naltrexone hydrochloride (NTX) (3.0 mg/kg, i.p.), L-NAME (1.0 μg/mouse, i.c.v.), S-MTC (1.0 μg/mouse, i.c.v.) or N5-(1-iminoethyl)-L-ornithine (L-NIO) (3.0 mg/kg, s.c.) 15-30 min prior to HBO2 treatment. The antinociceptive effect assessed 90 min after HBO2 treatment is completely abolished by NTX and L-NAME, antagonized by two-thirds by S-MTC and largely unaffected by L-NIO (F=25.57, p<0.0001)[2]. At a dose of 0.3 mg/kg, S-MTC (SMTC) causes a rise in mean blood pressure (BP). At doses of 1.0, 3.0 and 10 mg/kg, S-MTC causes falls in heart rate, rises in BP and vasoconstriction in all three vascular beds[3]. | | References | [1] Law A, et al. Neuroprotective and neurorescuing effects of isoform-specific nitric oxide synthase inhibitors, nitric oxide scavenger, and antioxidant against beta-amyloid toxicity. Br J Pharmacol. 2001 Aug;133(7):1114-24. DOI:10.1038/sj.bjp.0704179
[2] Zelinski LM, et al. A prolonged nitric oxide-dependent, opioid-mediated antinociceptive effect of hyperbaric oxygenin mice. J Pain. 2009 Feb;10(2):167-72. DOI:10.1016/j.jpain.2008.08.003
[3] Wakefield ID, et al. Comparative regional haemodynamic effects of the nitric oxide synthase inhibitors, S-methyl-L-thiocitrulline and L-NAME, in conscious rats. Br J Pharmacol. 2003 Jul;139(6):1235-43. DOI:10.1038/sj.bjp.0705351 |
| | S-Methyl-L-thiocitrulline Preparation Products And Raw materials |
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