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N-(4-Aminobutyl)-2-naphthalenesulfonamide hydrochloride

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N-(4-Aminobutyl)-2-naphthalenesulfonamide hydrochloride Basic information
Product Name:N-(4-Aminobutyl)-2-naphthalenesulfonamide hydrochloride
Synonyms:N-(4-AMINOBUTYL)-2-NAPHTHALENESULFONAMIDE HCL;N-(4-AMINOBUTYL)-2-NAPHTHALENESULPHONAMIDE HYDROCHLORIDE;W-12;W-12 HYDROCHLORIDE;N-(4-aminobutyl)-2-naphthalene-*sulfonamide hydro;W-12, HCl;N-(4-AMINOBUTYL)-2-NAPHTHALENE-SULFONAMI DE HYDROCH;N-(4-Aminobutyl)-2-naphthalenesulfonamide
CAS:89108-46-3
MF:C14H19ClN2O2S
MW:314.83
EINECS:
Product Categories:Protein Kinase Inhibitors and Activators;Amines;Aromatics;Sulfur & Selenium Compounds
Mol File:89108-46-3.mol
N-(4-Aminobutyl)-2-naphthalenesulfonamide hydrochloride Structure
N-(4-Aminobutyl)-2-naphthalenesulfonamide hydrochloride Chemical Properties
Melting point 181-182°C
storage temp. 2-8°C
solubility H2O: Stock solutions of approx. 5 mM are suggested. Stocks should be stable for at least 6 months when stored at 4°Csoluble
form powder
color yellow tan
Water Solubility water: 1mg/mL
ethanol: 5mg/mL
InChI1S/C14H18N2O2S.ClH/c15-9-3-4-10-16-19(17,18)14-8-7-12-5-1-2-6-13(12)11-14;/h1-2,5-8,11,16H,3-4,9-10,15H2;1H
InChIKeyWYFVKUWCEVMLOL-UHFFFAOYSA-N
CAS DataBase Reference89108-46-3(CAS DataBase Reference)
Safety Information
WGK Germany 3
HS Code 2935909099
Storage Class11 - Combustible Solids
MSDS Information
ProviderLanguage
SigmaAldrich English
N-(4-Aminobutyl)-2-naphthalenesulfonamide hydrochloride Usage And Synthesis
Chemical PropertiesWhite Solid
UsesCalmodulin antagonist that binds to calmodulin and inhibits calcium-ion-calmodulin- regulated activities, including phosphodiesterase activation and myosin light chain kinase
UsesN-(4-Aminobutyl)-2-naphthalenesulfonamide Hydrochloride is a calmodulin antagonist that binds calmodulin and inhibits calcium ion calmodulin-regulated activities such as phosphodiesterase activation and myosin light chain kinase (1, 2).
Biological ActivityCell permeable: yes', 'Primary Target
Myosin light chain kinase (Mlck)', 'Product does not compete with ATP.', 'Reversible: yes', 'Target IC50: 300 μM and 260 μM against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase, respectively.
N-(4-Aminobutyl)-2-naphthalenesulfonamide hydrochloride Preparation Products And Raw materials
Tag:N-(4-Aminobutyl)-2-naphthalenesulfonamide hydrochloride(89108-46-3) Related Product Information
Disulfiram N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide hydrochloride Naphthalene-2-sulfonamide 2-(Aminobutyl)-2-naphthalenesulfonamide hydrochloride N-(4-Aminobutyl)-2-naphthalenesulfonamide hydrochloride W-5 Isomer hydrochloride