N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE

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Products Intro: Product Name:W-13 hydrochloride
CAS:88519-57-7
Purity:98.51% Package:1mg;30USD|5mg;64USD|10mg;109USD Remarks:REAGENT;FOR LABORATORY USE ONLY
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Products Intro: Product Name:N-(4-Aminobutyl)-5-Chloronaphthalene-2-Sulfonamide Hydrochloride
CAS:88519-57-7
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Products Intro: Product Name:N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE
CAS:88519-57-7
Purity:N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLO Package:1g;5g;10g Remarks:98% HPLC
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Products Intro: Product Name:N-(4-Aminobutyl)-5-chloronaphthalene-2-sulfonamide hydrochloride
CAS:88519-57-7
Purity:95%+ Package:1g;5g;10g;25g;50g;100g; Remarks:accept Custom Synthesis Services, support large packing
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Products Intro: Product Name:W-13 hydrochloride
CAS:88519-57-7
Purity:95% Package:$74.9/5mg;$153.9/10mg;$256.9/25mg;$616.9/50mg;Bulk package Remarks:95%

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N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE Basic information
Product Name:N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE
Synonyms:W-13, Hydrochloride - CAS 88519-57-7 - Calbiochem;4-[(5-chloro-2-naphthalenyl)sulfonylamino]butylammonium;N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE;N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENE SULPHONAMIDE, HYDROCHLORIDE;OMEGA-13 HYDROCHLORIDE;W-13 HYDROCHLORIDE;N-(4-Aminohexyl)-5-chloro-2-naphthalenesulfonamide hydrochloride;(+)-5-Hydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-7-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
CAS:88519-57-7
MF:C14H18Cl2N2O2S
MW:349.28
EINECS:
Product Categories:All Inhibitors;Inhibitors;Protein Kinase Inhibitors and Activators;Calcium signaling;Amines;Aromatics;Sulfur & Selenium Compounds
Mol File:88519-57-7.mol
N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE Structure
N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE Chemical Properties
Melting point 241-243°C
storage temp. room temp
solubility H2O: Stock solutions of 5 mM are recommended. These stocks should be stable for up to 6 months when stored at 4°C.soluble
form powder
color white
Water Solubility water: 35mg/mL
InChI1S/C14H17ClN2O2S.ClH/c15-13-7-3-6-12-11(13)5-4-8-14(12)20(18,19)17-10-2-1-9-16;/h3-8,17H,1-2,9-10,16H2;1H
InChIKeyIKMXJMNRHREPOD-UHFFFAOYSA-N
SMILESCl.NCCCCNS(=O)(=O)c1cccc2c(Cl)cccc12
CAS DataBase Reference88519-57-7(CAS DataBase Reference)
Safety Information
Safety Statements 22-24/25
WGK Germany 3
HS Code 2935.90.9500
Storage Class11 - Combustible Solids
MSDS Information
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SigmaAldrich English
N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE Usage And Synthesis
DescriptionW-13 is a naphthalenesulfonamide derivative that acts as a potent antagonist of calmodulin (IC50 = 22 μM) and is widely used to investigate Ca2+/calmodulin-regulated enzyme activities.
Chemical PropertiesBeige Solid
UsesW-13 is a naphthalenesulfonamide derivative that acts as a potent antagonist of calmodulin (IC50 = 22 μM) and is widely used to investigate Ca2+/calmodulin-regulated enzyme activities.
UsesCalmodulin antagonist that binds to calmodulin and inhibits calcium-ion-calmodulin- regulated activities, including phosphodiesterase activation and myosin light chain kinase127, it is widely used to investigate Ca2+/calmodulin-regulated enzyme activities.
DefinitionChEBI: N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide hydrochloride is a hydrochloride salt prepared from equimolar amounts of N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide and hydrogen chloride. It contains a N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide(1+).
Biological ActivityCalmodulin antagonist (inhibits calmodulin activated PDE activity with an IC 50 of 68 μ M). Inhibits growth of tamoxifen-resistant breast cancer cells.
Biochem/physiol ActionsW-13 has also been shown to inhibit the transcytosis of IgA, recycling of transferrin and overall alter the endocytic pathway in Madin-Darby canine kidney cells.
storageStore at RT
References[1] N. KATAYAMA. A role for calmodulin in the growth of human hematopoietic progenitor cells.[J]. Blood, 1990, 75 7 1: 1446-1454. DOI: 10.1182/blood.v75.7.1446.bloodjournal7571446
[2] F. TEBAR. Calmodulin regulates intracellular trafficking of epidermal growth factor receptor and the MAPK signaling pathway.[J]. Molecular Biology of the Cell, 2002, 13 6 1: 2057-2068. DOI: 10.1091/mbc.01-12-0571
[3] PARIJAT SENGUPTA. Membrane-permeable calmodulin inhibitors (e.g. W-7/W-13) bind to membranes, changing the electrostatic surface potential: dual effect of W-13 on epidermal growth factor receptor activation.[J]. The Journal of Biological Chemistry, 2007, 282 11: 8474-8486. DOI: 10.1074/jbc.m607211200
N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE Preparation Products And Raw materials
Tag:N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE(88519-57-7) Related Product Information
N-TERT-BUTYL-ALPHA-PHENYLNITRONE BenzenesulfonaMide, 4-chloro-N-[1-(2-phenylethyl)-2-piperidinylidene]- (S)-3-aMino-4-(3-hexylphenylaMino)-4-oxobutylphosphonic acid (TFA salt) N-[[4-(DIMETHYLAMINO)PHENYL]METHYL]-1,2,3,4-TETRAHYDRO-7-METHOXY-N-[4-(1-METHYLETHYL)PHENYL]-1-NAPHTHALENECARBOXAMIDE HYDROCHLORIDE W-5 HYDROCHLORIDE W123 Exclusive [(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate) Naphthalene Carbon tetrachloride Propylene oxide N-(4-AMINOBUTYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE, HYDROCHLORIDE NAPHTHALENE-2-SULFONAMIDE 1-Chloronaphthalene 1,4-Diaminobutane dihydrochloride N-(4-AMINOBUTYL)-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE