PPADS TETRASODIUM SALT

PPADS TETRASODIUM SALT Suppliers list

Company Name:	3B Pharmachem (Wuhan) International Co.,Ltd.
Tel:	18930552037
Email:	3bsc@sina.com

Company Name:	ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel:	18149758185 18149758185
Email:	sales-cpd@caerulumpharma.com

PPADS TETRASODIUM SALT manufacturers

PPADS TETRASODIUM SALT Basic information

Product Name:	PPADS TETRASODIUM SALT
Synonyms:	PPADS Tetrasodium;PPADS tetrasodium salt, anhydrous;PPADS (sodium salt);4-[(2E)-2-[4-formyl-6-methyl-5-oxo-3-(phosphonatooxymethyl)pyridin-2-ylidene]hydrazinyl]benzene-1,3-disulfonate;PYRIDOXALPHOSPHATE-6-AZOPHENYL-2',4'-DISULFONIC ACID TETRASODIUM SALT;PYRIDOXALPHOSPHATE-6-AZOPHENYL-2',4'-DISULPHONIC ACID 4NA;PYRIDOXAL-PHOSPHATE-6-AZOPHENYL-2',4'-DISULPHONIC ACID TETRASODIUM;PPADS
CAS:	192575-19-2
MF:	C14H15N3NaO12PS2
MW:	535.37
EINECS:
Product Categories:	Adenosines/P2 Nucleotide Receptor - Antagonists;Adenosines/P2 Nucleotide Receptors (Purinergics);GPCR Modulators;GPCR Proteins;Ligand-Gated Ion Channels;Membrane Protein Biology Tools;Modulators and Antibodies;P2X Receptor Modulators;Proteins and Derivatives;Aldehydes;Antagonists;Bioactive Small Molecules;Biochemicals and Reagents;Building Blocks;C13-C60;Carbonyl Compounds;Cell Biology;Cell Signaling and Neuroscience;Chemical Synthesis;Ion Channels;Neuroscience;Neurotransmission;Neurotransmitters;Organic Building Blocks;P
Mol File:	192575-19-2.mol

PPADS TETRASODIUM SALT Chemical Properties

storage temp.	−20°C
solubility	H₂O: >10 mg/mL
form	solid
color	red to orange
Water Solubility	Soluble to 100 mM in water
Stability:	Unstable in Aqueous Solution
InChIKey	JTTDHFFNVGHDLN-YDTRVRFHSA-J
SMILES	O.[Na+].[Na+].[Na+].[Na+].Cc1nc(\N=N\c2ccc(cc2S([O-])(=O)=O)S([O-])(=O)=O)c(COP([O-])([O-])=O)c(C=O)c1O

Safety Information

MSDS Information

Provider	Language
SigmaAldrich	English

PPADS TETRASODIUM SALT Usage And Synthesis

Uses	P2X and P2Y purinergic receptors are ATP-sensitive receptors responsible for mediating a large variety of excitatory postsynaptic responses including fast transmission at central synapses, contraction of smooth muscle cells, platelet aggregation, macrophage activation, and apoptosis. PPADS is a non-selective P2 purinergic antagonist that blocks recombinant P2X1-5 (IC50s = 1-2.6 μM), native P2Y2-like (IC50 = ~0.9 mM), and recombinant P2Y4 (IC50 = ~15 mM) receptors. PPADS antagonism of ATP-sensitive P2 receptors produces neuroprotective effects in an ischemia model with permanent middle cerebral artery occlusion in spontaneously hypertensive rats.
Uses	PPADS Tetrasodium is an non-selective purinergic antagonists of P2 ATP receptors. PPADS Tetrasodium is also a potential neuroprotective agents for the treatment of autoimmune and demyelinating disease.
Definition	ChEBI: Tetrasodium 5'-phosphonatopyridoxal-6-azobenzene-2,4-disulfonate is an organic sodium salt that is the tetrasodium salt of 5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid It has a role as a purinergic receptor P2X antagonist. It is an organic sodium salt and an organosulfonate salt. It contains a 5'-phosphonatopyridoxal-6-azobenzene-2,4-disulfonate.
Biological Activity	Non-selective P2 purinoceptor antagonist which blocks responses at both pre- and post-junctional sites.
storage	-20°C (desiccate)

PPADS TETRASODIUM SALT Preparation Products And Raw materials

Tag:PPADS TETRASODIUM SALT(192575-19-2) Related Product Information

Pyridoxal phosphate PPADS TETRASODIUM SALT ISO-PPADS TETRASODIUM SALT PPADS TETRASODIUM SALT PYRIDOXAL-5'-PHOSPHATE-6-(2'-NAPHTHYLAZO-6'-NITRO-4',8'-DISULFONATE) TETRASODIUM SALT Tat-M2NX (trifluoroacetate salt)