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| | TRAP-6 amide trifluoroacetate salt Basic information |
| | TRAP-6 amide trifluoroacetate salt Chemical Properties |
| solubility | DMSO: 12 mg/mL
Ethanol: Slightly solublePBS (pH 7.2): 5 mg/mL |
| | TRAP-6 amide trifluoroacetate salt Usage And Synthesis |
| Description | TRAP-6 amide is a peptide agonist of proteinase-activated receptor 1 (PAR1).1 It induces platelet aggregation in vitro (EC50 = 0.15 µM). TRAP-6 amide (30 µM) induces relaxation of isolated guinea pig internal anal sphincter strips.2 It also increases cigarette smoke extract-induced IL-8 release from isolated human bronchial epithelial cells when used at a concentration of 50 µM.3WARNING This product is not for human or veterinary use. | | References | [1] J.T. ELLIOTT. Tritiated photoactivatable analogs of the native human thrombin receptor (PAR-1) agonist peptide, SFLLRN-NH2[J]. Chemical Biology & Drug Design, 2008, 57 6: 494-506. DOI: 10.1034/j.1399-3011.2001.00857.x
[2] HUANG S C. Proteinase-activated receptor-1 (PAR1) and PAR2 mediate relaxation of guinea pig internal anal sphincter[J]. Regulatory Peptides, 2014, 189: Pages 46-50. DOI: 10.1016/j.regpep.2014.03.001
[3] ANGELA MARINA MONTALBANO. Expression/Activation of PAR-1 in Airway Epithelial Cells of COPD Patients: Ex Vivo/In Vitro Study.[J]. International Journal of Molecular Sciences, 2021. DOI: 10.3390/ijms221910703 |
| | TRAP-6 amide trifluoroacetate salt Preparation Products And Raw materials |
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