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| | PAR3 (1-6) amide (mouse) (trifluoroacetate salt) Basic information |
| | PAR3 (1-6) amide (mouse) (trifluoroacetate salt) Chemical Properties |
| solubility | Water: 1 mg/ml |
| | PAR3 (1-6) amide (mouse) (trifluoroacetate salt) Usage And Synthesis |
| Description | PAR3 (1-6) amide is a synthetic hexapeptide that corresponds to amino acid residues 1-6 of the amino terminal tethered ligand sequence of mouse proteinase-activated receptor 3 (PAR3) and residues 38-43 of the full-length sequence. PAR3 (1-6) amide activates PAR1 and PAR2, but not PAR3 or PAR4.1,2 It does not induce thrombin signaling in COS-7 cells expressing PAR3, PAR4, or both receptors at concentrations less than or equal to 500 µM, however, it does activate PAR1 and PAR2 in a cross-desensitization assay in Jurkat T cells when used at concentrations of 500 and 1,000 µM.1,2 PAR3 (1-6) increases calcium levels in Kirsten virus-transformed rat kidney (KNRK) cells expressing rat or human PAR2, with a higher potency for rat PAR2.WARNING This product is not for human or veterinary use. | | References | [1] MAYUMI NAKANISHI-MATSUI. PAR3 is a cofactor for PAR4 activation by thrombin[J]. Nature, 2000, 404 6778: 609-613. DOI: 10.1038/35007085
[2] KRISTINA K. HANSEN Morley D H Mahmoud Saifeddine. Tethered ligand-derived peptides of proteinase-activated receptor 3 (PAR3) activate PAR1 and PAR2 in Jurkat T cells[J]. Immunology, 2004, 112 2: 183-190. DOI: 10.1111/j.1365-2567.2004.01870.x |
| | PAR3 (1-6) amide (mouse) (trifluoroacetate salt) Preparation Products And Raw materials |
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