(1E,6E)-1,7-双(3,4-二甲氧基苯基)-4-(4-羟基-3-甲氧基亚苄基)庚-1,6-二烯-3,5-二酮
| 中文名称 | (1E,6E)-1,7-双(3,4-二甲氧基苯基)-4-(4-羟基-3-甲氧基亚苄基)庚-1,6-二烯-3,5-二酮 |
|---|---|
| 中文同义词 | (1E,6E)-1,7-双(3,4-二甲氧基苯基)-4-(4-羟基-3-甲氧基亚苄基)庚-1,6-二烯-3,5-二酮;化合物NF-ΚB-IN-1;化合物NF-ΚB-IN-1,10 MM DMSO 溶液 |
| 英文名称 | 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- |
| 英文同义词 | 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-;AC17 NF-κB-IN-1;NF-κB-IN-1;NF-kB-IN-1(AC17);(1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-4-(4-hydroxy-3-methoxybenzylidene)hepta-1,6-diene-3,5-dione;pathway,4-arylidene,Inhibitor,inhibit,IKK,crucumin,cancer,A549,NFκBIN1,I kappa B kinase,signaling,NF κB IN 1,IκB kinase,NF-κB;T63;NF-κB-IN-1, 10 mM in DMSO |
| CAS号 | 1227098-15-8 |
| 分子式 | C31H30O8 |
| 分子量 | 530.57 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1227098-15-8.mol |
| 结构式 |  |
(1E,6E)-1,7-双(3,4-二甲氧基苯基)-4-(4-羟基-3-甲氧基亚苄基)庚-1,6-二烯-3,5-二酮 性质
| 沸点 | 732.0±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.233±0.06 g/cm3(Predicted) |
| 形态 | 固体 |
| 酸度系数(pKa) | 9.27±0.31(Predicted) |
| 颜色 | 浅黄至黄色 |
NF-κB-IN-1，一种 4-亚芳基姜黄素类似物，是有效的 NF-κB 信号通路抑制剂。NF-κB-IN-1 直接抑制 IKK 来阻断 NF-κB 的激活。NF-κB-IN-1 可有效抑制肺癌细胞的活力并减弱 A549 细胞的克隆活性。
IKK
NF-κB-IN-1 (compound 17) (0.001-100 μM; 72 h) inhibits the growth of A549, H1944, H460 and H157 cells, with GI
50
s of 0.72, 0.07, 0.13, and 0.16 μM, respectively.
NF-κB-IN-1 (0.5-25 μM; pretreated for 30 min or 4 h) potently blocks the IκB phosphorylation and degradation in A549 cells.
NF-κB-IN-1 (0.1-100 μM; pretreated for 30 min) dose-dependently inhibits the TNFα-induced nuclear translocation of NF-κB in A549 cells, with an IC
50
s of 1.0 μM.
NF-κB-IN-1 (0.1-0.4 μM; 9 d) inhibits lung cancer clonogenic activity.
Cell Viability Assay
| Cell Line: | A549, H1944, H460 and H157 cells |
| Concentration: | 0.001, 0.01, 0.1, 1, 10, 100 μM |
| Incubation Time: | 72 hours |
| Result: | Decreased viability of lung adenocarcinoma cells A549 and H1944, quamous cell carcinoma cells H157, and large cell carcinoma cells H460 in a dose-dependent manner. |
Western Blot Analysis
| Cell Line: | A549 cells |
| Concentration: | 0.5, 1.0, 2.5, 5.0, 10.0, 25.0 μM |
| Incubation Time: | Pretreated for 30 min or 4 h |
| Result: |
Blocked IκB phosphorylation, with an IC
50
of 2.8 μM.
Blocked IκB degradation in a dose-dependent manner. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-138537 | (1E,6E)-1,7-双(3,4-二甲氧基苯基)-4-(4-羟基-3-甲氧基亚苄基)庚-1,6-二烯-3,5-二酮 NF-κB-IN-1 | 1227098-15-8 | 1 mg | 1900元 |
| 2025/12/22 | HY-138537 | (1E,6E)-1,7-双(3,4-二甲氧基苯基)-4-(4-羟基-3-甲氧基亚苄基)庚-1,6-二烯-3,5-二酮 NF-κB-IN-1 | 1227098-15-8 | 5mg | 3800元 |