WM-3835 manufacturers
- WM-3835
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- $31.00
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2026-08-20
- CAS:2229025-70-9
- Purity: 99.36%
- Supply Ability: 10g
- WM-3835
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2026-07-06
- CAS:2229025-70-9
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1000kg
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| | WM-3835 Basic information |
| Product Name: | WM-3835 | | Synonyms: | WM-3835;invasion,MYST2,HBO1,WM3835,MYLK-HOXA9,Histone Acetyltransferase,Apoptosis,inhibit,H4K12ac,HATs,KAT7,WM-3835,migration,WM 3835,acetyl-CoA,HAT,OS) cell proliferation,osteosarcoma,H3K14ac,Inhibitor,pOS-1;N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)-3-hydroxybenzenesulfonohydrazide;[1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 2-[(3-hydroxyphenyl)sulfonyl]hydrazide;WM-3835, 10 mM in DMSO | | CAS: | 2229025-70-9 | | MF: | C20H17FN2O4S | | MW: | 400.42 | | EINECS: | | | Product Categories: | | | Mol File: | 2229025-70-9.mol |  |
| | WM-3835 Chemical Properties |
| density | 1.369±0.06 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | DMSO : 250 mg/mL (624.34 mM; Need ultrasonic) | | pka | 7.26±0.25(Predicted) | | form | Solid | | color | White to off-white | | InChI | 1S/C20H17FN2O4S/c1-13-10-15(14-6-3-2-4-7-14)11-18(19(13)21)20(25)22-23-28(26,27)17-9-5-8-16(24)12-17/h2-12,23-24H,1H3,(H,22,25) | | InChIKey | KVJFJJXCBRSCDY-UHFFFAOYSA-N | | SMILES | OC1=CC(S(NNC(C2=CC(C3=CC=CC=C3)=CC(C)=C2F)=O)(=O)=O)=CC=C1 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | WM-3835 Usage And Synthesis |
| Uses | WM-3835 is a potent and high-specific HBO1 (KAT7 or MYST2) inhibitor and binds directly to the acetyl-CoA binding site of HBO1. WM-3835 activates apoptosis while inhibits osteosarcoma (OS) cell proliferation, migration and invasion. WM-3835 has antitumor activity and potently inhibits pOS-1 xenograft growth in mice[1]. | | Biological Activity | WM-3835is a cell-permeable hydroxybenzenesulfonohydrazide compound th at acts as a potent, selective, Ac-CoA competitive and reversible inhibitor of HBO1, KAT6A, and TIP60 acetyltransferases (IC50 = 0.030, 0.017 and 0.312 μM, respectively). WM-3835 is non-cytotoxic, dose-dependently, and rapidly decreases H3K14Ac levels (IC50 = 0.341 μM) and inhibits AML cells growth (IC50 = 0.297 μM in Molm13). Induces apoptosis, downregulates HOXA and IL-6 expression and up-regulates ALB secretion and delays hepatocyte and hMPC senescence. WM-1385 potently inhibits POS-1 xenograft growth in SCID mice (10 mg/kg, i.p.). | | in vivo | WM-3835 (10 mg/kg/day; ip; for21 days) potently inhibits pOS-1 xenograft growth in SCID mice[1].
| Animal Model: | SCID mice (18-19 g, female) with pOS1 cells[1] | | Dosage: | 10 mg/kg | | Administration: | IP; daily; for 21 days | | Result: | Potently inhibited pOS-1 xenograft growth.
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| | IC 50 | HBO1 | | storage | Store at -20°C | | References | [1] Yan-Yang Gao, et al. The histone acetyltransferase HBO1 functions as a novel oncogenic gene in osteosarcoma. Theranostics. 2021 Mar 4;11(10):4599-4615. DOI:10.7150/thno.55655 |
| | WM-3835 Preparation Products And Raw materials |
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