Benzeneacetamide, 4-(aminosulfonyl)-N-[3-cyano-5-(cyclohexylmethyl)-4,5,6,7-tetrahydro-6,6-dimethylthieno[3,2-c]pyridin-2-yl]-

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Benzeneacetamide, 4-(aminosulfonyl)-N-[3-cyano-5-(cyclohexylmethyl)-4,5,6,7-tetrahydro-6,6-dimethylthieno[3,2-c]pyridin-2-yl]- Suppliers list
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Benzeneacetamide, 4-(aminosulfonyl)-N-[3-cyano-5-(cyclohexylmethyl)-4,5,6,7-tetrahydro-6,6-dimethylthieno[3,2-c]pyridin-2-yl]- manufacturers

  • NITD-688
  • NITD-688 pictures
  • $5790.00
  • 2026-07-21
  • CAS:2407227-31-8
  • Purity: 99.93%
  • Supply Ability: 10g
Benzeneacetamide, 4-(aminosulfonyl)-N-[3-cyano-5-(cyclohexylmethyl)-4,5,6,7-tetrahydro-6,6-dimethylthieno[3,2-c]pyridin-2-yl]- Basic information
Product Name:Benzeneacetamide, 4-(aminosulfonyl)-N-[3-cyano-5-(cyclohexylmethyl)-4,5,6,7-tetrahydro-6,6-dimethylthieno[3,2-c]pyridin-2-yl]-
Synonyms:Benzeneacetamide, 4-(aminosulfonyl)-N-[3-cyano-5-(cyclohexylmethyl)-4,5,6,7-tetrahydro-6,6-dimethylthieno[3,2-c]pyridin-2-yl]-;N-(3-Cyano-5-(cyclohexylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)-2-(4-sulfamoylphenyl)acetamide;NITD-688
CAS:2407227-31-8
MF:C25H32N4O3S2
MW:500.68
EINECS:
Product Categories:
Mol File:2407227-31-8.mol
Benzeneacetamide, 4-(aminosulfonyl)-N-[3-cyano-5-(cyclohexylmethyl)-4,5,6,7-tetrahydro-6,6-dimethylthieno[3,2-c]pyridin-2-yl]- Structure
Benzeneacetamide, 4-(aminosulfonyl)-N-[3-cyano-5-(cyclohexylmethyl)-4,5,6,7-tetrahydro-6,6-dimethylthieno[3,2-c]pyridin-2-yl]- Chemical Properties
density 1.34±0.1 g/cm3(Predicted)
pka10.06±0.10(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
Benzeneacetamide, 4-(aminosulfonyl)-N-[3-cyano-5-(cyclohexylmethyl)-4,5,6,7-tetrahydro-6,6-dimethylthieno[3,2-c]pyridin-2-yl]- Usage And Synthesis
UsesNITD-688 is an orally active pan-serotype inhibitor of the dengue virus NS4B protein. NITD-688 can be used in the research of dengue virus (DENV)[1].
in vivo

NITD-688 (30 mg/kg, oral gavage, twice daily for 3 days) demonstrates excellent antiviral efficacy in infected AG129 mice[1].
NITD-688 (15-300 mg/kg, oral gavage, per day for 7 days) is well tolerated in rats and dogs (toxicology studies)[1].

Animal Model:Infected AG129 mice[1]
Dosage:30 mg/kg
Administration:Oral gavage, twice daily for 3 days
Result:Resulted in a 1.16-log reduction in viremia.
References[1] Moquin SA, et al. NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models. Sci Transl Med. 2021 Feb 3;13(579):eabb2181. DOI:10.1126/scitranslmed.abb2181
Benzeneacetamide, 4-(aminosulfonyl)-N-[3-cyano-5-(cyclohexylmethyl)-4,5,6,7-tetrahydro-6,6-dimethylthieno[3,2-c]pyridin-2-yl]- Preparation Products And Raw materials
Tag:Benzeneacetamide, 4-(aminosulfonyl)-N-[3-cyano-5-(cyclohexylmethyl)-4,5,6,7-tetrahydro-6,6-dimethylthieno[3,2-c]pyridin-2-yl]-(2407227-31-8) Related Product Information
Benzeneacetamide, 4-(aminosulfonyl)-N-[3-cyano-5-(cyclohexylmethyl)-4,5,6,7-tetrahydro-6,6-dimethylthieno[3,2-c]pyridin-2-yl]- N-(3-cyano-6-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-(4-methylsulfonylphenyl)acetamide NA NA Brequinar Dynasore