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(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride

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(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride Suppliers list
Company Name: Shandong Luning Pharmaceutical Co., Ltd.
Tel: +8613675460589
Email: sale@lntzkg.com
Products Intro: Product Name:Tadalafil intermediate-API
CAS:171752-68-4
Purity:99% Package:1KG;0.00;USD
Company Name: HangZhou RunYan Pharma Technology Co.,LTD.
Tel: +86-18882027439
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Products Intro: Product Name:(1R,3R)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-1-(3,4-METHYLENEDIOXYPH ENYL), METHYL ESTER, HYDROCHLORIDE
CAS:171752-68-4
Purity:99% HPLC Package:50g;|100g;|500g
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Products Intro: Product Name:2-[[(2'-Cyano[1,1'-biphenyl]-4-yl)methyl]amino]-3-nitro-benzoic acid ethyl ester
CAS:171752-68-4
Purity:99.99% Package:1kg;100USD
Company Name: Hangzhou ICH Biofarm Co., Ltd
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Products Intro: Product Name:cis-(1R,3R)-1,2,3,4-Tetrah ydro-1-(3,4-methylenedi oxyphenyl)-9H-pyrido[3, 4-b]indole-3-carboxylic acid methyl ester hydrochloride
CAS:171752-68-4
Purity:98.0%+ Package:1KG;|5KG;|25KG
Company Name: Anhui Ruihan Technology Co., Ltd
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Products Intro: Product Name:1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-
CAS:171752-68-4
Purity:99% Package:1kg;30USD

(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride manufacturers
(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride Basic information
Product Name:(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride
Synonyms:INTERMEDIATES OF TADALAFIL:(1R,3R)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-1-(3,4-METHYLENEDIOXYPH ENYL), METHYL ESTER, CIS ISOMER, HYDROCHLORIDE;1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-;1H-Pyrido[3,4-b]indole-3-carboxylicacid;methylester, monohydrochloride, (1R,3R)-;(1R,3R)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-1-(3,4-METHYLENEDIOXYPH ENYL), METHYL ESTER, HYDROCHLORIDE;CHEMPACIFIC 51475;cis-(1R,3R)-1,2,3,4-Tetrahydro-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester hydrochloride;(1R,3R)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID
CAS:171752-68-4
MF:C20H18N2O4.ClH
MW:386.83
EINECS:1592732-453-0
Product Categories:Intermediate of Tadalafil
Mol File:171752-68-4.mol
(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride Structure
(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride Chemical Properties
Melting point 239-241 °C
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMSO (Slightly, Sonicated), Methanol (Slightly)
form Solid
color Off-White to Pale Yellow
Stability:Hygroscopic
InChIInChI=1/C20H18N2O4.ClH/c1-24-20(23)15-9-13-12-4-2-3-5-14(12)21-19(13)18(22-15)11-6-7-16-17(8-11)26-10-25-16;/h2-8,15,18,21-22H,9-10H2,1H3;1H/t15-,18-;/s3
InChIKeyROYJOKDTCKPQHK-QHWQFTOMNA-N
SMILESC12[C@@H](C3=CC=C4OCOC4=C3)N[C@H](CC=1C1C(=CC=CC=1)N2)C(OC)=O.Cl |&1:1,12,r|
Safety Information
MSDS Information
(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride Usage And Synthesis
Uses(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride is a key pharmaceutical intermediate used in the synthesis of the drug tadalafil. Tadalafil is a phosphodiesterase 5 (PDE5) inhibitor primarily used to treat erectile dysfunction and benign prostatic hyperplasia in men.
PreparationD-tryptophan methyl ester hydrochloride and piperonal chloride dissolved in redistilled tetrahydrofuran and then added trifluoroacetic acid. Stir the reaction at 30 ° C for 10 h under the protection of nitrogen. Add sodium triacetoxyborohydride and continue the reaction for 3 hours. After the reaction is monitored by a TLC plate, the reaction solution is concentrated to about 10 mL, deionized water is added, and extracted with ethyl acetate twice. Saturated sodium chloride was washed twice, and dried under reduced pressure to obtain (1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride. The yield was 86.95%, the purity was 98.76%.
(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride
(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride Preparation Products And Raw materials
Tag:(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride(171752-68-4) Related Product Information
BENZHYDRYL 6,6-DIHYDROPENICILLIC ACID 1-OXIDE[TAZOBACTAM INTERMEDIATE] cis-ent-Tadalafil cis-Tadalafil 3-(4-Phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile (S)-1-Boc-3-hydroxypiperidine Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]- Trelagliptin succinate Tadalafil Hydroxytyrosol Benoxinate Hydrochloride Chloropretadalafil D-Tryptophan methyl ester hydrochloride (1S,3S)-1-(1,3-Benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester Tadalafil EP IMpurity G Tadalafil Impurity 11 Tadalafil Impurity 39 Tadalafil Impurity 62