(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one

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(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one manufacturers

  • Darbufelone
  • Darbufelone pictures
  • $30.00
  • 2026-08-30
  • CAS:139226-28-1
  • Purity: 99.77%
  • Supply Ability: 10g
  • Darbufelone
  • Darbufelone pictures
  • $30.00
  • 2026-08-26
  • CAS:139226-28-1
  • Purity: 99.77%
  • Supply Ability: 10g
(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one Basic information
Product Name:(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one
Synonyms:(5z)-2-amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one;5-((z)-3,5-di-tert-butyl-4-hydroxybenzylidene)-2-imino-4-thiazolidinone;(Z)-2-AMino-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)thiazol-4(5H)-one;CS-490;(5Z)-2-amino-5-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]-1,3-thiazol-4-one;4(5H)-Thiazolone, 2-amino-5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-, (5Z)-;(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylide...;(5Z)-2-amino-5-[(3,5-ditert-butyl-4-hydroxyphenyl)
CAS:139226-28-1
MF:C18H24N2O2S
MW:332.46
EINECS:1312995-182-4
Product Categories:
Mol File:139226-28-1.mol
(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one Structure
(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one Chemical Properties
Boiling point 448.6±55.0 °C(Predicted)
density 1.18±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form Solid
pka9.98±0.50(Predicted)
color White to off-white
Safety Information
MSDS Information
(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one Usage And Synthesis
UsesDarbufelone is a dual inhibitor of cellular PGF2α and LTB4 production. Darbufelone potently inhibits PGHS-2 (IC50= 0.19 μM) but is much less potent with PGHS-1 (IC50=20 μM).
Biological ActivityDarbufelone is a dual inhibitor of cellular PGF2α and LTB4 production. It potently inhibits PGHS-2 (IC50=0.19 μM), but is much less potent against PGHS-1 (IC50=20 μM).
in vivoDarbufelone is a dual inhibitor of cellular PGF2R and LTB4 production. Darbufelone is orally active and nonulcerogenic in animal models of inflammation and arthritis.
target

IC50: 0.19 μM (PGHS-2), 20 μM (PGHS-1)

References[1] Johnson AR, et al. Slow-binding inhibition of human prostaglandin endoperoxide synthase-2 with darbufelone, an isoform-selective antiinflammatory di-tert-butyl phenol. Biochemistry. 2001 Jun 26;40(25):7736-45. DOI:10.1021/bi002343f
[2] Ye X, et al. Darbufelone, a novel anti-inflammatory drug, induces growth inhibition of lung cancer cells both in vitro and in vivo. Cancer Chemother Pharmacol. 2010 Jul;66(2):277-85. DOI:10.1007/s00280-009-1161-z
(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one Preparation Products And Raw materials
Tag:(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one(139226-28-1) Related Product Information
Phenol Thiazole DARBUFELONE MESILATE (5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one Xanthine oxidase-IN-11 4(5H)-Thiazolone,2-amino-5-(phenylmethylene)-