L-Ornithinamide, N-(13,13-dimethyl-1,11-dioxo-4,7,12-trioxa-10-azatetradec-1-yl)-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-

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L-Ornithinamide, N-(13,13-dimethyl-1,11-dioxo-4,7,12-trioxa-10-azatetradec-1-yl)-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- Suppliers list
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L-Ornithinamide, N-(13,13-dimethyl-1,11-dioxo-4,7,12-trioxa-10-azatetradec-1-yl)-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- Basic information
Product Name:L-Ornithinamide, N-(13,13-dimethyl-1,11-dioxo-4,7,12-trioxa-10-azatetradec-1-yl)-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-
Synonyms:L-Ornithinamide, N-(13,13-dimethyl-1,11-dioxo-4,7,12-trioxa-10-azatetradec-1-yl)-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-;BocNH-PEG2-C2-Val-Cit-PAB-OH;Boc-PEG2-Val-Cit-PAB-OH;Boc-NH-PEG2-Val-Cit-PAB
CAS:2055024-55-8
MF:C30H50N6O9
MW:638.75
EINECS:
Product Categories:
Mol File:2055024-55-8.mol
L-Ornithinamide, N-(13,13-dimethyl-1,11-dioxo-4,7,12-trioxa-10-azatetradec-1-yl)-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- Structure
L-Ornithinamide, N-(13,13-dimethyl-1,11-dioxo-4,7,12-trioxa-10-azatetradec-1-yl)-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- Chemical Properties
Boiling point 920.8±65.0 °C(Predicted)
density 1.203±0.06 g/cm3(Predicted)
pka12.23±0.46(Predicted)
Safety Information
MSDS Information
L-Ornithinamide, N-(13,13-dimethyl-1,11-dioxo-4,7,12-trioxa-10-azatetradec-1-yl)-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- Usage And Synthesis
UsesBoc-PEG2-Val-Cit-PAB-OH is an enzyme-cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The Boc protecting group may be removed with acid to reveal a primary amine which may be used in coupling reactions to form amides. The Val-Cit-PAB is cleaved by cellular proteases for efficient release of payloads to the cell.
L-Ornithinamide, N-(13,13-dimethyl-1,11-dioxo-4,7,12-trioxa-10-azatetradec-1-yl)-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- Preparation Products And Raw materials
Tag:L-Ornithinamide, N-(13,13-dimethyl-1,11-dioxo-4,7,12-trioxa-10-azatetradec-1-yl)-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-(2055024-55-8) Related Product Information
Boc-Val-Cit-PABA Val-Lys(Boc)-PAB L-Ornithinamide, N-[13-(9H-fluoren-9-yl)-1,11-dioxo-4,7,12-trioxa-10-azatridec-1-yl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- L-Ornithinamide, N-(19,19-dimethyl-1,17-dioxo-4,7,10,13,18-pentaoxa-16-azaeicos-1-yl)-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- L-Ornithinamide, N-(25,25-dimethyl-1,23-dioxo-4,7,10,13,16,19,24-heptaoxa-22-azahexacos-1-yl)-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- L-Ornithinamide, N-[3-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-1-oxopropyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-