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| | 5-Fluoro-2-methoxyaniline Basic information |
| | 5-Fluoro-2-methoxyaniline Chemical Properties |
| Melting point | 3 °C | | Boiling point | 90 °C/760 mmHg | | density | 1.1981 g/mL at 25 °C | | refractive index | n20/D 1.5438 | | Fp | 109 °C | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 3.52±0.10(Predicted) | | form | clear liquid | | color | Colorless to Light yellow to Light orange | | CAS DataBase Reference | 1978-39-8 |
| Hazard Codes | Xn | | Risk Statements | 22-36/37/38 | | Safety Statements | 26 | | RIDADR | UN 2810 6.1/PG III | | WGK Germany | 3 | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 2921420090 |
| | 5-Fluoro-2-methoxyaniline Usage And Synthesis |
| Uses | 5-Fluoro-2-methoxyaniline was used in the study of structure-activity relationship to discover selective inhibitors of p97 ATPase. | | Synthesis | General procedure for the synthesis of 2-methoxy-5-fluoroaniline from 2-nitro-4-fluoroanisole: 4-fluoro-2-nitroanisole (85 g, 0.50 mol) was dissolved in methanol (300 mL) and palladium-carbon catalyst (10%, 8 g) was added. The reaction was stirred under hydrogen atmosphere for 15 hours. After completion of the reaction, the catalyst was removed by filtration, and the filtrate was concentrated to dryness to obtain the crude product 2-methoxy-5-fluoroaniline (61.5 g, 0.436 mol, 87% yield), which could be directly used in the next reaction without further purification. | | References | [1] Collection of Czechoslovak Chemical Communications, 1982, vol. 47, # 1, p. 72 - 87
[2] Patent: WO2005/26137, 2005, A2. Location in patent: Page/Page column 231
[3] Journal of Organic Chemistry, 1951, vol. 16, p. 1345,1348
[4] Journal of the American Chemical Society, 1959, vol. 81, p. 94,95, 97
[5] Journal of Organic Chemistry, 1952, vol. 17, p. 229,230 |
| | 5-Fluoro-2-methoxyaniline Preparation Products And Raw materials |
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