| Company Name: |
Alfa Aesar |
| Tel: |
400-6106006 |
| Email: |
saleschina@alfa-asia.com |
|
| | 4-Trifluoromethyl-3-fluorobenzyl alcohol Basic information |
| Product Name: | 4-Trifluoromethyl-3-fluorobenzyl alcohol | | Synonyms: | 3-Fluoro-4-(trifluoromethyl)benzenemethanol;2-Fluoro-4-(hydroxymethyl)benzotrifluoride, [3-Fluoro-4-(trifluoromethyl)phenyl]methanol;3-Fluoro-4-(trifluoromethyl)benzylalcohol97%;(3-Fluoro-4-(trifluoromethyl)phenyl)methanol;4-Trifluoromethyl-3-fluorob;Benzenemethanol, 3-fluoro-4-(trifluoromethyl)-;(3-Fluoro-4-(trifluoromethyl)phenyl)meth | | CAS: | 230295-16-6 | | MF: | C8H6F4O | | MW: | 194.13 | | EINECS: | | | Product Categories: | Fluorine series | | Mol File: | 230295-16-6.mol |  |
| | 4-Trifluoromethyl-3-fluorobenzyl alcohol Chemical Properties |
| Melting point | 28-32°C | | Boiling point | 209℃ | | density | 1.377 | | Fp | 80℃ | | storage temp. | Sealed in dry,Room Temperature | | pka | 13.76±0.10(Predicted) | | Appearance | Light green to green Solid-liquid mixture | | CAS DataBase Reference | 230295-16-6 |
| | 4-Trifluoromethyl-3-fluorobenzyl alcohol Usage And Synthesis |
| Synthesis | Step A: Preparation of (3-fluoro-4-(trifluoromethyl)phenyl)methanol: 3-fluoro-4-(trifluoromethyl)benzaldehyde (2.0 g, 10 mmol) and anhydrous methanol (20 mL) were added to a round-bottomed flask fitted with stirring bar. The flask was cooled in an ice bath, followed by the addition of sodium borohydride (0.47 g, 12 mmol) in batches. The ice bath was removed and the reaction mixture was allowed to warm naturally to room temperature. Saturated ammonium chloride solution (2 mL) was added and the mixture was subsequently concentrated under vacuum. The residue was diluted with additional saturated ammonium chloride solution (30 mL) and extracted with ethyl acetate (3 x 30 mL). The organic phases were combined, dried over magnesium sulfate, filtered and concentrated. Yield: 1.8 g (80%). The resulting product was used in the next reaction without further purification. | | References | [1] Patent: WO2014/78331, 2014, A1. Location in patent: Paragraph 00855 |
| | 4-Trifluoromethyl-3-fluorobenzyl alcohol Preparation Products And Raw materials |
|