Ethanol, 2-[2-[4-(5-oxidodibenzo[b,f][1,4]thiazepin-11-yl)-1-piperazinyl]ethoxy]- ,dihydrochloride

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Ethanol, 2-[2-[4-(5-oxidodibenzo[b,f][1,4]thiazepin-11-yl)-1-piperazinyl]ethoxy]- ,dihydrochloride Basic information
Product Name:Ethanol, 2-[2-[4-(5-oxidodibenzo[b,f][1,4]thiazepin-11-yl)-1-piperazinyl]ethoxy]- ,dihydrochloride
Synonyms:Quetiapine sulfoxide (dihydrochloride);Quetiapine EP Impurity S DiHCl (Quetiapine Sulfoxide DiHCl);Quetiapine EP Impurity S HCl Salt;Quetiapine S-oxide dihydrochloride;QUETIAPINE SULFOXIDE DIHYDROCHLORIDE; QUETIAPINE S-OXIDE DIHYDROCHLORIDE;11-(4-(2-(2-Hydroxyethoxy)ethyl)piperazin-1-yl)dibenzo[b,f][1,4]thiazepine 5-oxide dihydrochloride;Ethanol, 2-[2-[4-(5-oxidodibenzo[b,f][1,4]thiazepin-11-yl)-1-piperazinyl]ethoxy]- ,dihydrochloride
CAS:329218-11-3
MF:C21H26ClN3O3S
MW:435.97
EINECS:
Product Categories:
Mol File:329218-11-3.mol
Ethanol, 2-[2-[4-(5-oxidodibenzo[b,f][1,4]thiazepin-11-yl)-1-piperazinyl]ethoxy]- ,dihydrochloride Structure
Ethanol, 2-[2-[4-(5-oxidodibenzo[b,f][1,4]thiazepin-11-yl)-1-piperazinyl]ethoxy]- ,dihydrochloride Chemical Properties
storage temp. Store at -20°C
form Solid
color White to yellow
Water Solubility Water: 250 mg/mL (529.18 mM)
Safety Information
MSDS Information
Ethanol, 2-[2-[4-(5-oxidodibenzo[b,f][1,4]thiazepin-11-yl)-1-piperazinyl]ethoxy]- ,dihydrochloride Usage And Synthesis
UsesQuetiapine sulfoxide dihydrochloride (Quetiapine S-oxide dihydrochloride) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic[1]. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist[2].
in vivo

The Cmax value (mean±SD) is estimated for Quetiapine sulfoxide (77.3±32.4 ng/mL). The AUClast value is estimated for Quetiapine sulfoxide (1,286±458 ngh/mL). For Quetiapine sulfoxide, metabolic ratio decreases with time, from 119% on average 2 hours after dosing to 30% on average 72 hours after dosing[1].

References[1] Remmerie B, et al. Comparison of Capillary and Venous Drug Concentrations After Administration of a Single Dose of Risperidone, Paliperidone, Quetiapine, Olanzapine, or Aripiprazole. Clin Pharmacol Drug Dev. 2016 Nov;5(6):528-537. DOI:10.1002/cpdd.290
[2] Cross AJ, et al. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. Br J Pharmacol. 2016 Jan;173(1):155-66. DOI:10.1111/bph.13346
Ethanol, 2-[2-[4-(5-oxidodibenzo[b,f][1,4]thiazepin-11-yl)-1-piperazinyl]ethoxy]- ,dihydrochloride Preparation Products And Raw materials
Tag:Ethanol, 2-[2-[4-(5-oxidodibenzo[b,f][1,4]thiazepin-11-yl)-1-piperazinyl]ethoxy]- ,dihydrochloride(329218-11-3) Related Product Information
Angeli’s Salt Lignosulfonic acid 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepin hydrochloride Ethanol, 2-[2-[4-(5-oxidodibenzo[b,f][1,4]thiazepin-11-yl)-1-piperazinyl]ethoxy]- ,dihydrochloride 11-(Piperazin-1-yl)dibenzo[b,f][1,4]thiazepine Quetiapine sulfoxide 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride 1-[2(2-Hydroxyethoxy)ethyl]piperazine dihydrochloride Quetiapine