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Urea, N-(3-fluoro-2-methylphenyl)-N'-(8-hydroxy-1,1-dioxido-2H-1-benzothiopyran-7-yl)- manufacturers
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| | Urea, N-(3-fluoro-2-methylphenyl)-N'-(8-hydroxy-1,1-dioxido-2H-1-benzothiopyran-7-yl)- Basic information |
| | Urea, N-(3-fluoro-2-methylphenyl)-N'-(8-hydroxy-1,1-dioxido-2H-1-benzothiopyran-7-yl)- Chemical Properties |
| Boiling point | 474.3±45.0 °C(Predicted) | | density | 1.538±0.06 g/cm3(Predicted) | | pka | 6.28±0.20(Predicted) |
| | Urea, N-(3-fluoro-2-methylphenyl)-N'-(8-hydroxy-1,1-dioxido-2H-1-benzothiopyran-7-yl)- Usage And Synthesis |
| Uses | CXCR2 antagonist 3 (compound 11h) is a potent antagonist of CXC chemokine receptor 2 (CXCR2). CXCR2 antagonist 3 demonstrates double-digit nanomolar potencies against CXCR2 and significantly inhibited neutrophil infiltration into the air pouch. CXCR2 antagonist 3 reduces the infiltration of neutrophils and MDSCs and enhance the infiltration of CD3+ T lymphocytes into the Pan02 tumor tissues[1]. | | References | [1] Dong Y, et al. Discovery of Benzocyclic Sulfone Derivatives as Potent CXCR2 Antagonists for Cancer Immunotherapy. J Med Chem. 2021;64(22):16626-16640. DOI:10.1021/acs.jmedchem.1c01219 |
| | Urea, N-(3-fluoro-2-methylphenyl)-N'-(8-hydroxy-1,1-dioxido-2H-1-benzothiopyran-7-yl)- Preparation Products And Raw materials |
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