Urea, N-(3,4-dihydro-8-hydroxy-1,1-dioxido-2H-1-benzothiopyran-7-yl)-N'-(3-fluoro-2-methylphenyl)-

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Urea, N-(3,4-dihydro-8-hydroxy-1,1-dioxido-2H-1-benzothiopyran-7-yl)-N'-(3-fluoro-2-methylphenyl)- manufacturers
Urea, N-(3,4-dihydro-8-hydroxy-1,1-dioxido-2H-1-benzothiopyran-7-yl)-N'-(3-fluoro-2-methylphenyl)- Basic information
Product Name:Urea, N-(3,4-dihydro-8-hydroxy-1,1-dioxido-2H-1-benzothiopyran-7-yl)-N'-(3-fluoro-2-methylphenyl)-
Synonyms:Urea, N-(3,4-dihydro-8-hydroxy-1,1-dioxido-2H-1-benzothiopyran-7-yl)-N'-(3-fluoro-2-methylphenyl)-;CXCR2 antagonist 2
CAS:2647464-91-1
MF:C17H17FN2O4S
MW:364.39
EINECS:
Product Categories:
Mol File:2647464-91-1.mol
Urea, N-(3,4-dihydro-8-hydroxy-1,1-dioxido-2H-1-benzothiopyran-7-yl)-N'-(3-fluoro-2-methylphenyl)- Structure
Urea, N-(3,4-dihydro-8-hydroxy-1,1-dioxido-2H-1-benzothiopyran-7-yl)-N'-(3-fluoro-2-methylphenyl)- Chemical Properties
Boiling point 473.4±45.0 °C(Predicted)
density 1.504±0.06 g/cm3(Predicted)
storage temp. 4°C, away from moisture and light
form Solid
pka6.68±0.20(Predicted)
color Off-white to light yellow
Safety Information
MSDS Information
Urea, N-(3,4-dihydro-8-hydroxy-1,1-dioxido-2H-1-benzothiopyran-7-yl)-N'-(3-fluoro-2-methylphenyl)- Usage And Synthesis
Description

CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunotherapy with an IC50 value of 95 nM.

UsesCXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunoresearch with an IC50 value of 95 nM.
References[1] Dong Y, et al. Discovery of Benzocyclic Sulfone Derivatives as Potent CXCR2 Antagonists for Cancer Immunotherapy. J Med Chem. 2021 Nov 25;64(22):16626-16640. DOI:10.1021/acs.jmedchem.1c01219
Urea, N-(3,4-dihydro-8-hydroxy-1,1-dioxido-2H-1-benzothiopyran-7-yl)-N'-(3-fluoro-2-methylphenyl)- Preparation Products And Raw materials
Tag:Urea, N-(3,4-dihydro-8-hydroxy-1,1-dioxido-2H-1-benzothiopyran-7-yl)-N'-(3-fluoro-2-methylphenyl)-(2647464-91-1) Related Product Information
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