| Company Name: |
MQ (shanghai) Pharmaceuticals Co., Ltd.
|
| Tel: |
13761635123 |
| Email: |
sales@linyuepharm.com |
| Products Intro: |
Product Name:1,3-Bis(2,4-dihydroxyphenyl)propan-1-one
CAS:240797-64-2
Purity:＞95% Package:1G，5G
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| Company Name: |
Bide Pharmatech Ltd.
|
| Tel: |
400-1647117 13681763483 |
| Email: |
product02@bidepharm.com |
| Products Intro: |
Product Name:1,3-Bis(2,4-dihydroxyphenyl)propan-1-one
CAS:240797-64-2
Purity:98% Package:25mg;50mg;100mg;250mg;1g Remarks:BD01934187
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| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Tyrosinase-IN-11
CAS:240797-64-2
Package:25mg/RMB 10600;50mg/RMB 13800;100mg/RMB 17500
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1-Propanone, 1,3-bis(2,4-dihydroxyphenyl)- manufacturers
- Tyrosinase-IN-11
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- $1520.00
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2026-05-11
- CAS:240797-64-2
- Purity:
- Supply Ability: 10g
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| | 1-Propanone, 1,3-bis(2,4-dihydroxyphenyl)- Basic information |
| | 1-Propanone, 1,3-bis(2,4-dihydroxyphenyl)- Chemical Properties |
| Melting point | 228-229 °C | | Boiling point | 578.3±35.0 °C(Predicted) | | density | 1.429±0.06 g/cm3(Predicted) | | pka | 7.70±0.35(Predicted) | | form | Solid | | color | Pink to orange |
| | 1-Propanone, 1,3-bis(2,4-dihydroxyphenyl)- Usage And Synthesis |
| Uses | Tyrosinase-IN-11 is a potent tyrosinase inhibitor with IC50s of 50 nM and 64 nM for L-tyrosinase and L-dopa, respectively. Tyrosinase-IN-11 has significant antioxidant activity and low cytotoxicity. Tyrosinase-IN-11 has the potential for skin hyperpigmentation research[1]. | | in vivo | Tyrosinase-IN-11 (compound 11c; 0.5, 1 mM; topical administration before UV radiation every day for 2 weeks or after exposure to UV lamp for 5 days/week for two consecutive weeks) exhibits powerful antimelanogenesis ability in a guinea pig model in vivo[1].
| Animal Model: | Female guinea pigs (10 weeks old, 350-500 g) received ultraviolet exposure from a UV lamp[1] | | Dosage: | 0.5, 1 mM | | Administration: | Topical administration before UV radiation every day for 2 weeks or after exposure to UV lamp for 5 days/week for two consecutive weeks | | Result: | Inhibited the production of melanin in a dose-dependent manner.
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| | References | [1] Songtao Xue, et al. Design, Synthesis, and Biological Evaluation of Novel Hybrids Containing Dihydrochalcone as Tyrosinase Inhibitors to Treat Skin Hyperpigmentation. J Med Chem. 2023 Apr 13;66(7):5099-5117. DOI:10.1021/acs.jmedchem.3c00012 |
| | 1-Propanone, 1,3-bis(2,4-dihydroxyphenyl)- Preparation Products And Raw materials |
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