3'-Guanylic acid, guanylyl-(3'→5')-, cyclic nucleotide, diammonium salt (9CI)

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3'-Guanylic acid, guanylyl-(3'→5')-, cyclic nucleotide, diammonium salt (9CI) Basic information
Product Name:3'-Guanylic acid, guanylyl-(3'→5')-, cyclic nucleotide, diammonium salt (9CI)
Synonyms:3'-Guanylic acid, guanylyl-(3'→5')-, cyclic nucleotide, diammonium salt (9CI);5GP-5GP diammonium|||c-di-GMP diammonium;5GP-5GP diammonium|||c-di-GMP diammonium|||cyclic diguanylate diammonium;cyclic diguanylate diammonium;Cyclic-di-GMP diammonium
CAS:609343-82-0
MF:C20H27N11O14P2
MW:707.45
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Mol File:609343-82-0.mol
3'-Guanylic acid, guanylyl-(3'→5')-, cyclic nucleotide, diammonium salt (9CI) Structure
3'-Guanylic acid, guanylyl-(3'→5')-, cyclic nucleotide, diammonium salt (9CI) Chemical Properties
storage temp. Store at -20°C
form Solid
color White to off-white
Safety Information
MSDS Information
3'-Guanylic acid, guanylyl-(3'→5')-, cyclic nucleotide, diammonium salt (9CI) Usage And Synthesis
UsesCyclic-di-GMP diammonium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP diammonium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP diammonium can be used in cancer research[1][2][3][4].
Biological ActivityCyclic di-GMP (c-di-GMP) diammonium is a STING activator and a global bacterial second messenger, which regulates biofilm formation, motility, and virulence in diverse bacterial species[1][2].
in vivo

Cyclic-di-GMP diammonium (100 μg/per; i.v.; two sequential vaccinations 9 days apart) enhances TriVax-induced immune responses to melanoma in mice and further increased the anti-tumor effects of TriVax[3].

Animal Model:C57BL/6 (B6) mice (8- to 10-week-old)[3].
Dosage:100 μg/per
Administration:Intravenous injection; two sequential vaccinations 9 days apart; combine with TriVax.
Result:Significantly higher numbers of antigen-specific CD8 T cells when combined with TriVax. (TriVax consisted of a mixture of 120 μg Pam-hgp100, 100 μg hgp100 or 100 μg Ova, 50 or 25 μg anti-CD40 antibody, and 25 μg Poly-IC).
Enhanced the anti-tumor activity of TriVax.
References[1]. Wang Z, et al. STING activator c-di-GMP enhances the anti-tumor effects of peptide vaccines in melanoma-bearing mice. Cancer Immunol Immunother. 2015;64(8):1057-1066. [2]. Burdette DL, et al. STING is a direct innate immune sensor of cyclic di-GMP. Nature. 2011 Sep 25;478(7370):515-8.
3'-Guanylic acid, guanylyl-(3'→5')-, cyclic nucleotide, diammonium salt (9CI) Preparation Products And Raw materials
Tag:3'-Guanylic acid, guanylyl-(3'→5')-, cyclic nucleotide, diammonium salt (9CI)(609343-82-0) Related Product Information
Guanosine 5'-(tetrahydrogen triphosphate), 2'-deoxy-, compd. with N,N-diethylethanamine (1:) 3'-O-(2-Methoxyethyl)guanosine 2'-Deoxyguanosine-5'-O-(1-thiotriphosphate), RP-isomer sodium salt GDP-L-Fuc.2Na 3'-Guanylic acid, guanylyl-(3'→5')-, cyclic nucleotide, diammonium salt (9CI) 7-methylguanosine triphosphate