| Company Name: |
Alfa Aesar |
| Tel: |
400-6106006 |
| Email: |
saleschina@alfa-asia.com |
| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
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sales8178@energy-chemical.com |
2-Amino-5-chlorobenzyl alcohol manufacturers
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| | 2-Amino-5-chlorobenzyl alcohol Basic information |
| | 2-Amino-5-chlorobenzyl alcohol Chemical Properties |
| Melting point | 107-109 °C(lit.) | | Boiling point | 320.7±27.0 °C(Predicted) | | density | 1.341±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 13.94±0.10(Predicted) | | Appearance | White to off-white Solid | | CAS DataBase Reference | 37585-25-4 |
| | 2-Amino-5-chlorobenzyl alcohol Usage And Synthesis |
| Synthesis | GENERAL PROCEDURE: A solution was prepared by dissolving 2-amino-5-chlorobenzoic acid (8.5 mmol) in THF (24 mL) at room temperature. This solution was added dropwise to a suspension of lithium aluminum hydride (20.4 mmol) in THF (10 mL) over 20 minutes. The reaction mixture was stirred continuously for 3.5 h at room temperature. Subsequently, water (10 mL) was added slowly at 0 °C to quench the reaction. The resulting suspension was filtered through a diatomaceous earth plug and washed with EtOAc (100 mL). The organic phase was washed with brine (30 mL), dried over anhydrous MgSO4 and finally concentrated under vacuum to give 2-amino-5-chlorobenzyl alcohol. | | References | [1] ACS Catalysis, 2013, vol. 3, # 4, p. 622 - 624
[2] Organic Letters, 2017, vol. 19, # 12, p. 3219 - 3222
[3] Tetrahedron Letters, 2017, vol. 58, # 40, p. 3795 - 3799
[4] Patent: WO2010/37533, 2010, A1. Location in patent: Page/Page column 44
[5] Organic Letters, 2016, vol. 18, # 21, p. 5572 - 5575 |
| | 2-Amino-5-chlorobenzyl alcohol Preparation Products And Raw materials |
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