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Product Name:Naxagolide
CAS:88058-88-2
Purity:95% Remarks:Reach out to us for more information about custom solutions.
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Naxagolide manufacturers
- Naxagolide
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- $1.00
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2020-01-13
- CAS:88058-88-2
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 1ton
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| | Naxagolide Basic information |
| Product Name: | Naxagolide | | Synonyms: | (+)-4-Propyl-9-hydroxynaphoxazine;(4aR)-3,4,4aβ,5,6,10bα-Hexahydro-4-propyl-2H-naphth[1,2-b]-1,4-oxazin-9-ol;4-Propyl-9-hydroxynaphoxazine;L-64739;2H-Naphth(1,2-B)-1,4-oxazin-9-ol, 3,4,4A,5,6,10B-hexahydro-4-propyl-, (4ar-trans)-;Naxagolida;Naxagolida [inn-spanish];Naxagolide [inn] | | CAS: | 88058-88-2 | | MF: | C15H21NO2 | | MW: | 247.336 | | EINECS: | 200-258-5 | | Product Categories: | | | Mol File: | 88058-88-2.mol |  |
| | Naxagolide Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO : 200 mg/mL (808.64 mM; Need ultrasonic) | | form | Solid | | color | White to off-white |
| | Naxagolide Usage And Synthesis |
| Uses | Antiparkinsonian;dopamine agonist. | | Definition | ChEBI: Naxagolide is an organic heterotricyclic compound that is (4aR,10bR)-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazine substituted by propyl and hydroxy groups at positions 4 and 9, respectively. It is a potent dopamine D2-receptor agonist and its hydrochloride salt was under clinical development by Merck & Co as a potential antiparkinsonian agent (now discontinued). It has a role as an antiparkinson drug, a dopamine agonist and an anticonvulsant. It is a tertiary amino compound, an organic heterotricyclic compound and a member of phenols. It is a conjugate base of a naxagolide(1+). | | in vivo | In mice, Naxagolide ((+)-PHNO) produces hypothermia (13 μg/kg i.p.) and postural asymmetry in the unilaterally caudectomized animal (4 μg/kg i.p.)[1].
In the rat, Naxagolide ((+)-PHNO) produces stereotypy (10 μg/kg i.p.) and contralateral turning in 6-hydroxydopamine-lesioned animals (5 μg/kg i.p.) that lasted 1 to 3 hr[1]. | | IC 50 | D2 Receptor |
| | Naxagolide Preparation Products And Raw materials |
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