- (S)-(+)-Glycidylnosylate
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- $0.00 / 1KG
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2025-12-12
- CAS:115314-14-2
- Min. Order: 1KG
- Purity: 98
- Supply Ability: 1KG 100KG 1MT
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| | (S)-(+)-Glycidyl nosylate Basic information | | Uses |
| | (S)-(+)-Glycidyl nosylate Chemical Properties |
| Melting point | 61-65 °C | | alpha | 21.5 º (c=2, CHCl3) | | Boiling point | 432.2±20.0 °C(Predicted) | | density | 1.5881 (rough estimate) | | refractive index | 1.5270 (estimate) | | storage temp. | Inert atmosphere,2-8°C | | solubility | Soluble in chloroform, methylene chloride and tetrahydrofuran. Insoluble in hexane. | | form | Needles or Powder | | color | Off-white to yellow-brown | | Sensitive | Moisture Sensitive | | InChI | InChI=1S/C9H9NO6S/c11-10(12)7-2-1-3-9(4-7)17(13,14)16-6-8-5-15-8/h1-4,8H,5-6H2/t8-/m0/s1 | | InChIKey | AIHIHVZYAAMDPM-QMMMGPOBSA-N | | SMILES | C1(S(OC[C@@H]2CO2)(=O)=O)=CC=CC([N+]([O-])=O)=C1 | | CAS DataBase Reference | 115314-14-2(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38-5 | | Safety Statements | 37/39-26-36 | | RIDADR | UN 1325 4.1/PG II | | RTECS | DB7192010 | | HazardClass | 4.1 | | PackingGroup | II | | HS Code | 29209090 |
| | (S)-(+)-Glycidyl nosylate Usage And Synthesis |
| Uses | (S)-(+)-Glycidyl Nosylate is a compound useful in organic synthesis. | | Chemical Properties | white to light yellow crystal powde | | Uses | (S)-(+)-Glycidyl Nosylate (cas# 115314-14-2) is a compound useful in organic synthesis. | | Synthesis | General procedure for the synthesis of (S)-(+)-m-nitrobenzenesulfonic acid glycidyl ester from 3-nitrobenzenesulfonyl chloride and (R)-oxirane-2-methanol: at -20 °C, m-nitrobenzenesulfonyl chloride (12.6 g, 57 mmol) was slowly added to a solution containing (R)-(+)-glycidol (5.5 g, 74 mmol) and triethylamine (TEA, 10.3 mL. 74 mmol) in a cold solution. The reaction mixture was stirred continuously at -20 °C for 96 hours. Upon completion of the reaction, the reaction solution was filtered and the filtrate was washed sequentially with 10% (w/w) aqueous tartaric acid, saturated saline and deionized water. The washed organic phase was concentrated to afford the target product (S)-(+)-m-nitrobenzenesulfonic acid glycidyl ester in 97% yield. The structure of the product was confirmed by 1H NMR (CDCl3): δ 2.62 (dd, 1H), 2.84 (dd, 1H), 3.22 (m, 1H), 4.07 (dd, 1H), 4.49 (dd, 1H), 7.80 (t, 1H), 8.25 (m, 1H), 8.52 (m, 1H), 8.78 (m, 1H). | | References | [1] Angewandte Chemie - International Edition, 2013, vol. 52, # 20, p. 5305 - 5308
[2] Angew. Chem., 2013, vol. 125, # 20, p. 5413 - 5416,4
[3] European Journal of Organic Chemistry, 2014, vol. 2014, # 19, p. 4053 - 4069
[4] Patent: US2004/229900, 2004, A1. Location in patent: Page 14
[5] Organic and Biomolecular Chemistry, 2006, vol. 4, # 16, p. 3067 - 3076 |
| | (S)-(+)-Glycidyl nosylate Preparation Products And Raw materials |
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