2,4-Pyrimidinediamine, N4-(8-methyl-4-cinnolinyl)-N2-[4-(4-morpholinyl)phenyl]-

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2,4-Pyrimidinediamine, N4-(8-methyl-4-cinnolinyl)-N2-[4-(4-morpholinyl)phenyl]- Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

2,4-Pyrimidinediamine, N4-(8-methyl-4-cinnolinyl)-N2-[4-(4-morpholinyl)phenyl]- manufacturers

  • ALK5-IN-33
  • ALK5-IN-33 pictures
  • $1980.00
  • 2026-07-27
  • CAS:2785430-89-7
  • Purity:
  • Supply Ability: 10g
2,4-Pyrimidinediamine, N4-(8-methyl-4-cinnolinyl)-N2-[4-(4-morpholinyl)phenyl]- Basic information
Product Name:2,4-Pyrimidinediamine, N4-(8-methyl-4-cinnolinyl)-N2-[4-(4-morpholinyl)phenyl]-
Synonyms:2,4-Pyrimidinediamine, N4-(8-methyl-4-cinnolinyl)-N2-[4-(4-morpholinyl)phenyl]-;ALK5-IN-33
CAS:2785430-89-7
MF:C23H23N7O
MW:413.48
EINECS:
Product Categories:
Mol File:2785430-89-7.mol
2,4-Pyrimidinediamine, N4-(8-methyl-4-cinnolinyl)-N2-[4-(4-morpholinyl)phenyl]- Structure
2,4-Pyrimidinediamine, N4-(8-methyl-4-cinnolinyl)-N2-[4-(4-morpholinyl)phenyl]- Chemical Properties
Boiling point 690.5±65.0 °C(Predicted)
density 1.341±0.06 g/cm3(Predicted)
pka6.00±0.40(Predicted)
Safety Information
MSDS Information
2,4-Pyrimidinediamine, N4-(8-methyl-4-cinnolinyl)-N2-[4-(4-morpholinyl)phenyl]- Usage And Synthesis
UsesALK5-IN-33 (Compound EX-10) is a selective, orally active ALK-5 inhibitor with an IC50 ≤10 nM[1].
in vivo

ALK-IN-33 (Compound EX-10) (10-100 mg/kg; i.g.; once) reduces the phospho SMAD2 levels in a dose dependent fashion in A549 xenograft model in mice[1].

Animal Model:Female athymic nude mice, A549 xenograft model[1]
Dosage:10, 50, 75 and 100 mg/kg
Administration:Oral gavage, once
Result:Reduced the phospho SMAD2 levels (p-SMAD2) in a dose dependent fashion.
IC 50ALK5: ≤10 nM (IC50); ALK2
References[1] Bettina FRANZ, et al. Alk-5 inhibitors and uses thereof. Patent WO2022126133A1.
2,4-Pyrimidinediamine, N4-(8-methyl-4-cinnolinyl)-N2-[4-(4-morpholinyl)phenyl]- Preparation Products And Raw materials
Tag:2,4-Pyrimidinediamine, N4-(8-methyl-4-cinnolinyl)-N2-[4-(4-morpholinyl)phenyl]-(2785430-89-7) Related Product Information
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