| Company Name: |
D&C Chemicals |
| Tel: |
+86-21-58447131 |
| Email: |
1724405207@qq.com |
- Fluoroclebopride
-
- $68.00
-
2026-07-27
- CAS:154540-49-5
- Purity: 99.80%
- Supply Ability: 10g
|
| | 4-Amino-5-chloro-N-(1-((4-fluorophenyl)methyl)-4-piperidinyl)-2-methox ybenzamide Basic information |
| Product Name: | 4-Amino-5-chloro-N-(1-((4-fluorophenyl)methyl)-4-piperidinyl)-2-methox ybenzamide | | Synonyms: | 4-Amino-5-chloro-N-(1-((4-fluorophenyl)methyl)-4-piperidinyl)-2-methox ybenzamide;fluoroclebopride;Benzamide,4-amino-5-chloro-N-[1-[(4-fluorophenyl)methyl]-4-piperidinyl]-2-methoxy-;Inhibitor,inhibit,Fluoroclebopride,Dopamine Receptor;Fluoroclebopride, 10 mM in DMSO;Abmole M4962-50mg fluoroclebopride 154540-49-5;Abmole M4962-10mg fluoroclebopride 154540-49-5 | | CAS: | 154540-49-5 | | MF: | C20H23ClFN3O2 | | MW: | 391.87 | | EINECS: | | | Product Categories: | | | Mol File: | 154540-49-5.mol |  |
| | 4-Amino-5-chloro-N-(1-((4-fluorophenyl)methyl)-4-piperidinyl)-2-methox ybenzamide Chemical Properties |
| Boiling point | 518.2±50.0 °C(Predicted) | | density | 1.31±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml | | form | A crystalline solid | | pka | 13.62±0.20(Predicted) | | color | White to off-white |
| | 4-Amino-5-chloro-N-(1-((4-fluorophenyl)methyl)-4-piperidinyl)-2-methox ybenzamide Usage And Synthesis |
| Description | Fluoroclebopride is a benzamide analog that is used in positron emission tomography (PET) applications. It binds reversibly to dopamine receptors (Kis = 0.95, 5.7, 5.46, and 144 nM for D2-like, D2(long), D3, and D4 receptors, respectively, in radioligand binding assays). It is selective for these receptors over D1, serotonin 5-HT2, and α2-adrenergic receptors (Kis = >10,000, 283, and 1,300 nM, respectively). A fluorine-18 moiety has been used to label this compound for use as a probe for studying D2/D3 receptor availability via PET in various monkey models. | | Uses | Fluoroclebopride binds reversibly to dopamine receptors. 18F labeled fluoroclebopride has been used as a probe for studying D2/D3 receptor availability via PET in various monkey models[1][2]. | | References | [1] Nader MA, Czoty PW. PET imaging of dopamine D2 receptors in monkey models of cocaine abuse: genetic predisposition versus environmental modulation. Am J Psychiatry. 2005 Aug;162(8):1473-82. DOI:10.1176/appi.ajp.162.8.1473
[2] Czoty PW, et al. Effects of repeated treatment with the dopamine D2/D3 receptor partial agonist aripiprazole on striatal D2/D3 receptor availability in monkeys. Psychopharmacology (Berl). 2013 Sep 29:10.1007/s00213-013-3274-7. DOI:10.1007/s00213-013-3274-7. doi: 10.1007/s00213-013-3274-7 |
| | 4-Amino-5-chloro-N-(1-((4-fluorophenyl)methyl)-4-piperidinyl)-2-methox ybenzamide Preparation Products And Raw materials |
|