10H-Phenothiazine-10-propanamide, 2-chloro-N,N-bis(4-fluorophenyl)-

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10H-Phenothiazine-10-propanamide, 2-chloro-N,N-bis(4-fluorophenyl)- Suppliers list
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10H-Phenothiazine-10-propanamide, 2-chloro-N,N-bis(4-fluorophenyl)- manufacturers
10H-Phenothiazine-10-propanamide, 2-chloro-N,N-bis(4-fluorophenyl)- Basic information
Product Name:10H-Phenothiazine-10-propanamide, 2-chloro-N,N-bis(4-fluorophenyl)-
Synonyms:10H-Phenothiazine-10-propanamide, 2-chloro-N,N-bis(4-fluorophenyl)-;20S Proteasome activator 1
CAS:2761578-18-9
MF:C27H19ClF2N2OS
MW:492.97
EINECS:
Product Categories:
Mol File:2761578-18-9.mol
10H-Phenothiazine-10-propanamide, 2-chloro-N,N-bis(4-fluorophenyl)- Structure
10H-Phenothiazine-10-propanamide, 2-chloro-N,N-bis(4-fluorophenyl)- Chemical Properties
Boiling point 713.8±60.0 °C(Predicted)
density 1.380±0.06 g/cm3(Predicted)
pka-1.46±0.20(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
10H-Phenothiazine-10-propanamide, 2-chloro-N,N-bis(4-fluorophenyl)- Usage And Synthesis
Uses20S Proteasome activator 1 is a potent 20S proteasome activator with EC200 values of 0.3 μM, 0.7 μM and 1.8 μM for trypsin-like site, chymotrypsin-like site and caspase-like site. 20S Proteasome activator 1 translates well in a cellular system, preventing the accumulation of the pathogenic A53T mutant of α-synuclein. 20S Proteasome activator 1 can be used for researching neurodegenerative diseases[1].
References[1] Staerz SD, et al. Design, Synthesis, and Biological Evaluation of Potent 20S Proteasome Activators for the Potential Treatment of α-Synucleinopathies. J Med Chem. 2022 May 12;65(9):6631-6642. DOI:10.1021/acs.jmedchem.1c02158
10H-Phenothiazine-10-propanamide, 2-chloro-N,N-bis(4-fluorophenyl)- Preparation Products And Raw materials
Tag:10H-Phenothiazine-10-propanamide, 2-chloro-N,N-bis(4-fluorophenyl)-(2761578-18-9) Related Product Information
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