| Company Name: |
Hangzhou Sage Chemical Co., Ltd.
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| Tel: |
+86057186818502 13588463833 |
| Email: |
info@sagechem.com |
| Products Intro: |
Product Name:3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-Methyl-, Methyl ester, hydrochloride
CAS:61-94-9
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| | ARECOLINE HYDROCHLORIDE Basic information |
| Product Name: | ARECOLINE HYDROCHLORIDE | | Synonyms: | ARECOLINE HYDROCHLORIDE;RARECHEM AX KI 5022;3-pyridinecarboxylicacid,1,2,5,6-tetrahydro-1-methyl-,methylester,hydroc;nicotinicacid,1,2,5,6-tetrahydro-1-methyl-,methylester,hydrochloride;methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate hydrochloride;3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-Methyl-, Methyl ester, hydrochloride;methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate hydrochloride;ethyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate hydrochloride | | CAS: | 61-94-9 | | MF: | C8H14ClNO2 | | MW: | 191.66 | | EINECS: | 200-523-6 | | Product Categories: | | | Mol File: | 61-94-9.mol |  |
| | ARECOLINE HYDROCHLORIDE Chemical Properties |
| Melting point | 157-158 °C(Solv: ethyl ether (60-29-7)) | | form | Solid | | CAS DataBase Reference | 61-94-9 |
| Toxicity | dni-mus-ipr 60 mg/kg IJEBA6 17,1141,79 |
| | ARECOLINE HYDROCHLORIDE Usage And Synthesis |
| Uses | Arecoline hydrochloride, a naturally occurring psychoactive alkaloid, is a partial agonist of nicotinic and muscarinic acetylcholine receptor. Arecoline hydrochloride exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline hydrochloride also can induce oxidative stress[1][2][3][4]. | | Safety Profile | Poison by intraperitoneal andintravenous routes. Questionable carcinogen withexperimental carcinogenic data. Whenheated to decomposition it emits very toxic fumes of NOxand HCl. | | References | [1] Thangjam GS, et, al. Regulation of oxidative-stress responsive genes by arecoline in human keratinocytes. J Periodontal Res. 2009 Oct;44(5):673-82. DOI:10.1111/j.1600-0765.2008.01176.x
[2] Liu YJ, et, al. The pharmacology, toxicology and potential applications of arecoline: a review. Pharm Biol. 2016 Nov;54(11):2753-2760. DOI:10.3109/13880209.2016.1160251
[3] Volgin AD, et, al. DARK Classics in Chemical Neuroscience: Arecoline. ACS Chem Neurosci. 2019 May 15;10(5):2176-2185. DOI:10.1021/acschemneuro.8b00711
[4] Kuo TM, et, al. Arecoline induces TNF-alpha production and Zonula Occludens-1 redistribution in mouse Sertoli TM4 cells. J Biomed Sci. 2014 Sep 9;21(1):93. DOI:10.1186/s12929-014-0093-z |
| | ARECOLINE HYDROCHLORIDE Preparation Products And Raw materials |
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