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| | 2,3-Dichlorobenzonitrile Basic information |
| | 2,3-Dichlorobenzonitrile Chemical Properties |
| Melting point | 60-64 °C(lit.) | | Boiling point | 114°C 6mm | | density | 1.4980 (rough estimate) | | refractive index | 1.6000 (estimate) | | Fp | 114°C/6mm | | storage temp. | Sealed in dry,Room Temperature | | form | Solid:bulk | | color | White to Light yellow to Green | | Water Solubility | It is miscible with water. | | BRN | 2438753 | | Exposure limits | NIOSH: IDLH 25 mg/m3 | | LogP | 2.83 | | CAS DataBase Reference | 6574-97-6(CAS DataBase Reference) |
| | 2,3-Dichlorobenzonitrile Usage And Synthesis |
| Chemical Properties | white powder | | Uses | 2,3-Dichlorobenzonitrile, is used as a reactant involved in nucleophilic aromatic fluorination, reactions with magnesium amides for synthesis of carboxamides, Suzuki-Miyaura coupling reactions. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dye stuff. | | Synthesis | General procedure for the synthesis of 2,3-dichlorobenzonitrile from 2,3-dichlorobenzaldehyde oxime: n-C4F9SO2F (20.0 mmol, 2.0 eq.) was slowly added dropwise using a syringe to a solution of dichloromethane (CH2Cl2, 20 mL) containing the substrate 2,3-dichlorobenzaldehyde oxime (10.0 mmol) and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU. 50.0 mmol, 5.0 equiv) in a solution of dichloromethane (CH2Cl2, 20 mL). The reaction mixture was stirred at the same temperature for 10 min. Subsequently, the volatile components were removed by distillation under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with the eluent being a solvent mixture of petroleum ether and ethyl acetate, resulting in the target product 2,3-dichlorobenzonitrile in 95% yield. | | References | [1] Tetrahedron Letters, 2010, vol. 51, # 14, p. 1826 - 1831
[2] Chinese Chemical Letters, 2016, vol. 27, # 1, p. 96 - 98 |
| | 2,3-Dichlorobenzonitrile Preparation Products And Raw materials |
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