| Company Name: |
DC Chemicals |
| Tel: |
021-58447131 13564518121 |
| Email: |
doncunbiosci@gmail.com |
4A3-SC8 manufacturers
- 4A3-SC8
-
-
2026-04-29
- CAS:1857340-78-3
- Min. Order: 10mg
- Purity: 98%
- Supply Ability: 1g
|
| | 4A3-SC8 Basic information |
| | 4A3-SC8 Chemical Properties |
| Boiling point | 1127.383±65.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.068±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | solubility | Chloroform: Soluble
Ethanol: Soluble | | form | Liquid | | pka | 9.329±0.50(predicted) | | color | Colorless to light yellow | | InChIKey | HMIDEMNFLBUNTB-UHFFFAOYSA-N | | SMILES | N(CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC)(CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC)CCCN(C)CCCN(CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC)CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC |
| | 4A3-SC8 Usage And Synthesis |
| Uses | 4A3-SC8 is a modular degradable dendrimer that enables small RNAs to extend survival in an aggressive liver cancer model[1]. | | in vivo | 4A3-SC8 mediates siRNA accumulation mainly in liver and slightly in the spleen and kidneys 24 hours after intravenous injection at dosage of 1 mg siRNA/kg and enables >95% FVII knockdown in mice[1].
After injection with 4A3-SC8 (100 mg/kg with 4 mg/kg control siRNA siCTR; i.v.; once), mice became sick and lost nearly 20% of their weight on the first day postinjection[1]. | | References | [1] Zhou K, et al. Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):520-5. DOI:10.1073/pnas.1520756113
[2] ÁLVAREZ-BENEDICTO E, FARBIAK L, RAMÍREZ M M, et al. Optimization of phospholipid chemistry for improved lipid nanoparticle (LNP) delivery of messenger RNA (mRNA)†[J]. Biomaterials Science, 2021, 2: 549-559. DOI: 10.1039/d1bm01454d
[3] LUKAS FARBIAK. All-In-One Dendrimer-Based Lipid Nanoparticles Enable Precise HDR-Mediated Gene Editing In Vivo[J]. Advanced Materials, 2021, 33 30. DOI: 10.1002/adma.202006619
[4] HU XIONG . Theranostic dendrimer-based lipid nanoparticles containing PEGylated BODIPY dyes for tumor imaging and systemic mRNA delivery in vivo[J]. Journal of Controlled Release, 2020, 325: Pages 198-205. DOI: 10.1016/j.jconrel.2020.06.030 |
| | 4A3-SC8 Preparation Products And Raw materials |
|