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| | (S,R,S)-AHPC-C3-NH2 hydrochloride/VH032-C3-NH2 Basic information |
| Product Name: | (S,R,S)-AHPC-C3-NH2 hydrochloride/VH032-C3-NH2 | | Synonyms: | (S,R,S)-AHPC-C3-NH2 hydrochloride/VH032-C3-NH2;(2S,4R)-1-[(2S)-2-(4-aminobutanoylamino)-3,3-dimethyl-butanoyl]-4-hydroxy-N-[[4-(4-methylthiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide hydrochloride;(2S,4R)-1-[(S)-2-(4-Aminobutanamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-[4-(4-methyl-5-thiazolyl)benzyl]pyrrolidine-2-carboxamide Hydrochloride;(2S,4R)-1-((S)-2-(4-aminobutanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride | | CAS: | 2940858-65-9 | | MF: | C26H37N5O4S.ClH | | MW: | 552.13 | | EINECS: | | | Product Categories: | | | Mol File: | 2940858-65-9.mol |  |
| | (S,R,S)-AHPC-C3-NH2 hydrochloride/VH032-C3-NH2 Chemical Properties |
| form | Solid | | color | Light yellow to yellow |
| | (S,R,S)-AHPC-C3-NH2 hydrochloride/VH032-C3-NH2 Usage And Synthesis |
| Uses | (S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used inPROTACtechnology[1]. | | IC 50 | VHL | | References | [1] Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. DOI:10.1016/j.csbj.2019.01.006
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277 |
| | (S,R,S)-AHPC-C3-NH2 hydrochloride/VH032-C3-NH2 Preparation Products And Raw materials |
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