GB-1-155

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GB-1-155 Suppliers list
Company Name: Shanghai Beckham Medical Technology Co., Ltd  
Tel: 13816613772
Email: huahero21@sina.com
Company Name: Shanghai Tachizaki Biomedical Research Center  
Tel: 18014399201
Email: sales@chemlab-tachizaki.com
Company Name: Nantong QuanYi Biotechnology Co., Ltd  
Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
GB-1-155 Basic information
Product Name:GB-1-155
Synonyms:GB-1-155;JGB-1-155
CAS:3011930-28-9
MF:C26H38N2O3
MW:426.59
EINECS:
Product Categories:
Mol File:3011930-28-9.mol
GB-1-155 Structure
GB-1-155 Chemical Properties
Boiling point 554.5±35.0 °C(predicted)
density 1.052±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka4.83±0.12(predicted)
Safety Information
MSDS Information
GB-1-155 Usage And Synthesis
UsesJGB-1-155 is a positive allosteric modulators (N-PAMs), which enhances the activity of nicotinamide phosphoribosyltransferase NAMPT with EC50 of 3.29 μM. JGB-1-155 counteracts the oxidative stress, through upregulating the NAD+ in THP-1 human monocytes. JGB-1-155 attenuates TNFα-induced ROS in HT-22 cells [1].
References[1] Gordon-Blake J, et al., Nicotinamide Phosphoribosyltransferase Positive Allosteric Modulators Attenuate Neuronal Oxidative Stress. ACS Med Chem Lett. 2024 Jan 24;15(2):205-214. DOI:10.1021/acsmedchemlett.3c00391
GB-1-155 Preparation Products And Raw materials
Tag:GB-1-155(3011930-28-9) Related Product Information
GNE 617 DPN NUCLEOSIDASE Nampt-IN-3 Acetamide, 2-[2-(1,1-dimethylethyl)phenoxy]-N-(4-hydroxyphenyl)- Acetamide, 2-[2-cyano-6-(1,1-dimethylethyl)phenoxy]-N-(4-hydroxyphenyl)- 2-Propenamide, N-[4-[1-(3-aminobenzoyl)-4-piperidinyl]butyl]-3-(3-pyridinyl)-, (2E)-