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| | dutomycin Basic information |
| Product Name: | dutomycin | | Synonyms: | dutomycin;1,4,6,7(6aH,10H)-Naphthacenetetrone, 8-acetyl-10-[[5-[[2,6-dideoxy-4-O-(2,4-dimethyl-1-oxo-2-heptenyl)-3-C-methyl-α-L-xylo-hexopyranosyl]oxy]tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-10a,11-dihydro-5,6a,9,10a-tetrahydroxy-2-methoxy-12-methyl-, [2S-[2α(6aR*,10S*,10aS*),5β(2Z,4S*),6α]]- (9CI) | | CAS: | 146663-67-4 | | MF: | C44H54O17 | | MW: | 854.89 | | EINECS: | | | Product Categories: | | | Mol File: | 146663-67-4.mol |  |
| | dutomycin Chemical Properties |
| Boiling point | 1023.6±65.0 °C(Predicted) | | density | 1.43±0.1 g/cm3(Predicted) | | pka | 4.05±0.70(Predicted) |
| | dutomycin Usage And Synthesis |
| Uses | Dutomycin is a SERPINB6 inhibitor with a binding constant (KD) of 1.236 μM. Dutomycin can induce autophagy and apoptosis in cancer cells and inhibit the growth of cancer cells in a zebrafish xenograft model. Dutomycin is promising for research of cancers[1]. | | Definition | ChEBI: Dutomycin is an anthracycline antibiotic of formula C44H54O17 isolated from Streptomyces species. It directly binds to the human serine protease inhibitor B6 (SERPINB6), inducing autophagy and apoptosis. It has a role as a bacterial metabolite, an autophagy inducer, an apoptosis inducer and an antineoplastic agent. It is an anthracycline antibiotic, a tertiary alpha-hydroxy ketone, a member of phenols, an ether, a member of 1,4-benzoquinones, a disaccharide derivative, an enol, an enoate ester, a carbopolycyclic compound and a carbohydrate-containing antibiotic. | | References | [1] Jang M, et al. Dutomycin Induces Autophagy and Apoptosis by Targeting the Serine Protease Inhibitor SERPINB6. ACS Chem Biol. 2021 Feb 19;16(2):360-370. DOI:10.1021/acschembio.0c00889 |
| | dutomycin Preparation Products And Raw materials |
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