| Company Name: |
TargetMol |
| Tel: |
400-821-0310 15002144251 |
| Email: |
xuexiang.shao@tsbiochem.com |
|
| | Actisomide Basic information |
| Product Name: | Actisomide | | Synonyms: | Actisomide;(4R,4aR)-4-[2-(Diisopropylamino)ethyl]-1-methyl-4-phenyl-4,4a,5,6 ,7,8-hexahydro-3H-pyrido[1,2-c]pyrimidin-3-one;(+/-)-trans-4-<2-ethyl>-4,4a,5,6,7,8-hexahydro-1-methyl-4-phenyl-3H-pyrido<1,2-c>-pyrimidin-3-one;3H-Pyrido[1,2-c]pyrimidin-3-one, 4-[2-[bis(1-methylethyl)amino]ethyl]-4,4a,5,6,7,8-hexahydro-1-methyl-4-phenyl-, (4R,4aR)-rel- | | CAS: | 96914-39-5 | | MF: | C23H35N3O | | MW: | 369.54 | | EINECS: | | | Product Categories: | | | Mol File: | 96914-39-5.mol |  |
| | Actisomide Chemical Properties |
| Melting point | 201-202 °C(Solv: ethyl ether (60-29-7)) | | Boiling point | 473.9±55.0 °C(Predicted) | | density | 1.08±0.1 g/cm3(Predicted) | | pka | 10.51±0.28(Predicted) |
| | Actisomide Usage And Synthesis |
| Originator | Dizactamide ,ZYF Pharm Chemical | | Manufacturing Process | Hydrogenation of 4-diisopropylamino-2-phenyl-2-pyridin-2-yl-butyramide over
platinum oxide catalyst reduced the pyridine ring to a piperidine to give 4-
diisopropylamino-2-phenyl-2-piperidin-2-yl-butyramide as a white solid, MP:
107°-108°C. Structure was confirmed by proton, carbon-13-NMR spectra and
by elemental analysis.
2-(1-Acetylpiperidin-2-yl)-4-diisopropylamino-2-phenylbutyramide was
prepared by acetylation of above product with N,N-dimethylacetamide
dimethylacetal by heating at 80°C for about 14 hours. The acetamide melted
at 191°-192°C. The treatment of that intermediate with lithium aluminum
hydride led the newly introduced acetyl group to condense with the adjacent
amide nitrogen. There was thus obtained 4-(2-diisopropylaminoethyl)-1-
methyl-4-phenyl-4,4a,5,6,7,8-hexahydropyrido[1,2-c]pyrimidin-3-one, the
new anti-arrhythmic agent actisomide, MP: 70°-75°C. Its structure was
confirmed by proton NMR and infrared spectra and by elemental analysis. | | Brand name | Cardiac
depressant (anti-arrhythmic). | | Therapeutic Function | Cardiac depressant |
| | Actisomide Preparation Products And Raw materials |
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