ALPHA-CGRP (8-37) (RAT) manufacturers
- CGRP 8-37 (rat)
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- $399.00
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2026-07-16
- CAS:129121-73-9
- Purity: 98.11%
- Supply Ability: 10g
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| | ALPHA-CGRP (8-37) (RAT) Basic information |
| Product Name: | ALPHA-CGRP (8-37) (RAT) | | Synonyms: | H-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASP-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-GLU-ALA-PHE-NH2;CALCITONIN GENE RELATED PEPTIDE (8-37) RAT;ALPHA-CALCITONIN GENE-RELATED PEPTIDE (8-37) (RAT);ALPHA-CGRP (8-37) (RAT);VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2;VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASP-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-GLU-ALA-PHE-NH2;ALA-CYS-ASP-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2: ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2DISULFIDE BRIDGE CYS2-CYS7;α-CGRP (8-37) (mouse, rat) | | CAS: | 129121-73-9 | | MF: | C138H224N42O41 | | MW: | 3127.51 | | EINECS: | | | Product Categories: | Peptide;Calcitonin and CGRP receptor | | Mol File: | 129121-73-9.mol |  |
| | ALPHA-CGRP (8-37) (RAT) Chemical Properties |
| density | 1.47±0.1 g/cm3(Predicted) | | storage temp. | -20°C, protect from light | | solubility | H2O : 50 mg/mL (15.99 mM; Need ultrasonic) | | form | Solid | | color | White to off-white | | Water Solubility | Soluble to 1 mg/ml in water | | Sequence | H-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-OH |
| | ALPHA-CGRP (8-37) (RAT) Usage And Synthesis |
| Uses | Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist. | | in vivo | CGRP-(8-37) is effective in alleviating mechanical and thermal allodynia in a dose-dependent manner. The 50 nM dose is most efficacious for both forelimb and hindlimb responses. The period of efficacy is 10 min to onset for a duration of 20 min. Post-drug washout responses are not statistically significant compared to pre-drug responses[1]. Intrathecal administration of 5 nmol or 10 nmol of CGRP-(8-37), but not 1 nmol, induces a significant increase in hindpaw withdrawal latency. Intrathecal administration of CGRP-(8-37) not only reverses the SP-induced decrease in latency to both withdrawal responses but also mediates a significant increase in response latency compared to basal levels[2]. | | storage | Store at -20°C | | References | [1] Bennett AD, et al. Alleviation of mechanical and thermal allodynia by CGRP(8-37) in a rodent model of chroniccentral pain. Pain. 2000 May;86(1-2):163-75. DOI:10.1016/s0304-3959(00)00242-6
[2] Yu LC, et al. The calcitonin gene-related peptide antagonist CGRP8-37 increases the latency to withdrawalresponses in rats. Brain Res. 1994 Aug 8;653(1-2):223-30. DOI:10.1016/0006-8993(94)90393-x |
| | ALPHA-CGRP (8-37) (RAT) Preparation Products And Raw materials |
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