(2S)-N-benzyl-2-[(2S)-2-(2-hydroxyacetyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxamide

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(2S)-N-benzyl-2-[(2S)-2-(2-hydroxyacetyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxamide manufacturers

  • JTP-4819
  • JTP-4819 pictures
  • $1520.00
  • 2026-04-21
  • CAS:162203-65-8
  • Purity:
  • Supply Ability: 10g
(2S)-N-benzyl-2-[(2S)-2-(2-hydroxyacetyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxamide Basic information
Product Name:(2S)-N-benzyl-2-[(2S)-2-(2-hydroxyacetyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxamide
Synonyms:(2S)-N-benzyl-2-[(2S)-2-(2-hydroxyacetyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxamide;JTP 4819;1-Pyrrolidinecarboxamide, 2-[[(2S)-2-(hydroxyacetyl)-1-pyrrolidinyl]carbonyl]-N-(phenylmethyl)-, (2S)-;(S)-N-Benzyl-2-((S)-2-(2-hydroxyacetyl)pyrrolidine-1-carbonyl)pyrrolidine-1-carboxamide
CAS:162203-65-8
MF:C19H25N3O4
MW:359.42
EINECS:
Product Categories:
Mol File:162203-65-8.mol
(2S)-N-benzyl-2-[(2S)-2-(2-hydroxyacetyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxamide Structure
(2S)-N-benzyl-2-[(2S)-2-(2-hydroxyacetyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxamide Chemical Properties
Boiling point 673.5±55.0 °C(Predicted)
density 1.300±0.06 g/cm3(Predicted)
pka12.91±0.10(Predicted)
Safety Information
MSDS Information
(2S)-N-benzyl-2-[(2S)-2-(2-hydroxyacetyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxamide Usage And Synthesis
UsesJTP-4819 is a potent and specific inhibitor of prolyl endopeptidase (PREP) with IC50s of 0.83 nM (in rat brain supernatant) and 5.43 nM (in Flavobacterium meningosepticum). JTP-4819 has blood-brain penetration, also improves the retention time of amnesia rats induced by Scopolamine (HY-N2096)[1][2].
in vivo

JTP-4819 (1 and 3 mg/kg 1 hr before acquisition or at 3 and 10 mg/kg 1 hr before; p.o.) significantly prolonged the retention time in the one-trial passive avoidance test in rats with Scopolamine (HY-N2096)-induced amnesia[1].
JTP-4819 (1 mg/kg and 3 mg/kg; p.o.; single dose) causes a significant increase in ACh release in the frontal cortex and hippocampus of young rats, as well as in both brain regions of aged rats at higher dose[1].
JTP-4819 combinded with substance P, arginine-vasopressin or thyrotropin-releasing hormone, improves the retention time of rats with scopolamine-induced amnesia[1].

Brain pharmacokinetics in rats[2]

AUC0-300 min (μg·min)Cmax (μM)Brain/blood ratiot1/2β (min)
Unblound concentrations
Blood194716.784
Cortex2061.780.1377
Hippocampus1281.050.09105
Striatum1781.260.10128
Total tissue concentrations
Plasma423078.6130
Brain1451.470.034120
References[1] Toide K, et al. JTP-4819: a novel prolyl endopeptidase inhibitor with potential as a cognitive enhancer. J Pharmacol Exp Ther. 1995 Sep;274(3):1370-8. PMID:7562510
(2S)-N-benzyl-2-[(2S)-2-(2-hydroxyacetyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxamide Preparation Products And Raw materials
Tag:(2S)-N-benzyl-2-[(2S)-2-(2-hydroxyacetyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxamide(162203-65-8) Related Product Information
1-Butanone, 1-[(2S)-2-[[(2S)-2-(1H-imidazol-2-yl)-1-pyrrolidinyl]carbonyl]-1-pyrrolidinyl]-4-phenyl- Prolyl endopeptidase inhibitor 2 Z-GLY-PRO-PNA eurystatin A FAP-IN-8 ZPP