| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:JTP-4819
CAS:162203-65-8
Purity:98% Remarks:Reach out to us for more information about custom solutions.
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| Company Name: |
Shanghai Synchem Pharma Co., ltd
|
| Tel: |
21-619849051-1 18521059765 |
| Email: |
synchempharma@aliyun.com |
| Products Intro: |
Product Name:(2S)-N-benzyl-2-[(2S)-2-(2-hydroxyacetyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxamide
CAS:162203-65-8
Purity:98% Package:50g;500g;1kg or as requested
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(2S)-N-benzyl-2-[(2S)-2-(2-hydroxyacetyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxamide manufacturers
- JTP-4819
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- $1520.00
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2026-04-21
- CAS:162203-65-8
- Purity:
- Supply Ability: 10g
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| | (2S)-N-benzyl-2-[(2S)-2-(2-hydroxyacetyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxamide Basic information |
| | (2S)-N-benzyl-2-[(2S)-2-(2-hydroxyacetyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxamide Chemical Properties |
| Boiling point | 673.5±55.0 °C(Predicted) | | density | 1.300±0.06 g/cm3(Predicted) | | pka | 12.91±0.10(Predicted) |
| | (2S)-N-benzyl-2-[(2S)-2-(2-hydroxyacetyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxamide Usage And Synthesis |
| Uses | JTP-4819 is a potent and specific inhibitor of prolyl endopeptidase (PREP) with IC50s of 0.83 nM (in rat brain supernatant) and 5.43 nM (in Flavobacterium meningosepticum). JTP-4819 has blood-brain penetration, also improves the retention time of amnesia rats induced by Scopolamine (HY-N2096)[1][2]. | | in vivo | JTP-4819 (1 and 3 mg/kg 1 hr before acquisition or at 3 and 10 mg/kg 1 hr before; p.o.) significantly prolonged the retention time in the one-trial passive avoidance test in rats with Scopolamine (HY-N2096)-induced amnesia[1].
JTP-4819 (1 mg/kg and 3 mg/kg; p.o.; single dose) causes a significant increase in ACh release in the frontal cortex and hippocampus of young rats, as well as in both brain regions of aged rats at higher dose[1].
JTP-4819 combinded with substance P, arginine-vasopressin or thyrotropin-releasing hormone, improves the retention time of rats with scopolamine-induced amnesia[1].
Brain pharmacokinetics in rats[2]
| AUC0-300 min (μg·min) | Cmax (μM) | Brain/blood ratio | t1/2β (min) | | Unblound concentrations | | | | | | Blood | 1947 | 16.7 | | 84 | | Cortex | 206 | 1.78 | 0.13 | 77 | | Hippocampus | 128 | 1.05 | 0.09 | 105 | | Striatum | 178 | 1.26 | 0.10 | 128 | | Total tissue concentrations | | | | | | Plasma | 4230 | 78.6 | | 130 | | Brain | 145 | 1.47 | 0.034 | 120 |
| | References | [1] Toide K, et al. JTP-4819: a novel prolyl endopeptidase inhibitor with potential as a cognitive enhancer. J Pharmacol Exp Ther. 1995 Sep;274(3):1370-8. PMID:7562510 |
| | (2S)-N-benzyl-2-[(2S)-2-(2-hydroxyacetyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxamide Preparation Products And Raw materials |
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