|
|
| | 1H-pyrazolo[4,3-c]pyridine-3-carboxylic acid Basic information | | Application |
| | 1H-pyrazolo[4,3-c]pyridine-3-carboxylic acid Chemical Properties |
| Boiling point | 501.7±30.0 °C(Predicted) | | density | 1.617 | | storage temp. | 2-8°C | | pka | 1.54±0.30(Predicted) | | Appearance | Off-white to yellow Solid |
| | 1H-pyrazolo[4,3-c]pyridine-3-carboxylic acid Usage And Synthesis |
| Application | 1H-pyrazolo[4,3-C]pyridine-3-carboxylic acid is an intermediate in organic synthesis and pharmaceutical research and development, and can be used in laboratory organic synthesis and chemical and pharmaceutical synthesis processes. | | Synthesis | The general procedure for the synthesis of 1H-pyrazolo[4,3-c]pyridine-3-carboxylic acid and compound (CAS: 936923-48-7) using compound (CAS: 932702-12-0) as starting material was as follows: in a microwave reaction vessel, N,N-diisopropyl-1H-pyrazolo[4,3-c]pyridine-3-carboxamide (0.800 g. 0.00325 mol) was mixed with 10 M aqueous hydrogen chloride solution (3.00 mL). The mixture was heated at 120 °C for 10 min. Heating at high absorbance settings is required to avoid pressure buildup. After completion of the reaction, the reaction mixture was diluted with water and neutralized with 3 N sodium hydroxide solution. The resulting white precipitate was collected and analyzed and found to be a mixture of 1H-pyrazolo[4,3-c]pyridine-3-carboxylic acid (47%) and monoisopropylamide (25%). The mixture could be used in subsequent steps without further purification. | | References | [1] Patent: US2007/78147, 2007, A1. Location in patent: Page/Page column 69
[2] Patent: WO2007/56582, 2007, A1. Location in patent: Page/Page column 76 |
| | 1H-pyrazolo[4,3-c]pyridine-3-carboxylic acid Preparation Products And Raw materials |
|