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| | 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid Basic information |
| | 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid Chemical Properties |
| Melting point | 283°C(lit.) | | Boiling point | 374.9±42.0 °C(Predicted) | | density | 1.342±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Aqueous Base (Slightly), DMSO (Slightly), Methanol (Slightly) | | pka | 5.56±0.50(Predicted) | | form | Solid | | color | Beige | | Water Solubility | Slightly soluble in water. | | InChI | InChI=1S/C8H9NO3/c1-4-6(3-10)9-5(2)7(4)8(11)12/h3,9H,1-2H3,(H,11,12) | | InChIKey | YCIHQDVIAISDPS-UHFFFAOYSA-N | | SMILES | N1C(C=O)=C(C)C(C(O)=O)=C1C | | CAS DataBase Reference | 253870-02-9(CAS DataBase Reference) |
| Hazard Codes | Xi | | HS Code | 2933998090 |
| | 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid Usage And Synthesis |
| Description | 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid is an important organic intermediate to synthetize substituted pyrrole products. | | Uses | 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic Acid is useful for the synthesis of 5-Bromo-7-azaindolin-2-one derivatives which possesses in vitro activity against selected cancer cell lines. | | Uses | 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid is a yellow crystalline substance, mainly used as pharmaceutical intermediates. | | Application | 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid can be used to prepare a drug carrier (cRGD-PEG-N＝CH-R6-Por (cPRP) triblock copolymer) for achieving highly efficient synergistic combined chemotherapy-photodynamic cancer therapy. | | Synthesis | Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate (19.4 g, 100 mmol) was used as a raw material and dissolved in a solvent mixture of methanol (100 mL) and water (400 mL). A 5N KOH solution (200 mL) was slowly added under stirring conditions. The reaction mixture was heated to reflux and stirred continuously for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted with 5N HCl solution to 3. Subsequently, the precipitate was collected by filtration and washed with distilled water. Finally, the resulting solid was dried under vacuum to afford the target product 2,4-dimethyl-5-formyl-1H-pyrrole-3-carboxylic acid (15.5 g, 94% yield) as a yellow-brown solid. | | References | [1] Journal of Medicinal Chemistry, 2017, vol. 60, # 1, p. 248 - 262
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 1, p. 139 - 146
[3] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 10, p. 3062 - 3065
[4] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 14, p. 2782 - 2787
[5] Journal of Medicinal Chemistry, 2003, vol. 46, # 7, p. 1116 - 1119 |
| | 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid Preparation Products And Raw materials |
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