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| | 4-Methyl-2,2'-bipyridine Basic information | | Uses |
| Product Name: | 4-Methyl-2,2'-bipyridine | | Synonyms: | 2,2'-bipyridine, 4-methyl-;4-methyl-2-pyridin-2-ylpyridine;4-Methyl-[2,2']bipyridinyl;2-(4-methylpyridin-2-yl)pyridine;4-methyl-2,2'-dipyridyl;4-Methyl-2,2'-bipyridine;4-Methyl-2,2′-bipyridin;4-Methyl-2,2'-bipyridine | | CAS: | 56100-19-7 | | MF: | C11H10N2 | | MW: | 170.21 | | EINECS: | | | Product Categories: | API intermediates | | Mol File: | 56100-19-7.mol |  |
| | 4-Methyl-2,2'-bipyridine Chemical Properties |
| Melting point | 62-64 °C(Solv: ligroine (8032-32-4)) | | Boiling point | 296.6±25.0 °C(Predicted) | | density | 1.081±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 4.73±0.18(Predicted) | | Appearance | White to off-white Solid | | InChI | InChI=1S/C11H10N2/c1-9-5-7-13-11(8-9)10-4-2-3-6-12-10/h2-8H,1H3 | | InChIKey | OHSRAWAUPZWNKY-UHFFFAOYSA-N | | SMILES | C1(C2=NC=CC=C2)=NC=CC(C)=C1 |
| | 4-Methyl-2,2'-bipyridine Usage And Synthesis |
| Uses | 4-Methyl-2,2'-bipyridine is a useful compound for research. | | Synthesis | Example 2 Synthesis of 4-methyl-2-(2'-pyridinyl)pyridine: Tetrahydrofuran (10 ml) and isopropylmagnesium chloride (2.0 M, 7.7 ml, 15.5 mmol) were added to a 50 ml flask under nitrogen protection. Subsequently, a solution prepared from 2-bromopyridine (2.45 g, 15.5 mmol) dissolved in tetrahydrofuran (3 ml) was added slowly and dropwise over 10 min. The reaction mixture was stirred for 1 hour and then a solution prepared from 4-methyl-2-benzenesulfonylpyridine (3.00 g, 12.9 mmol) dissolved in tetrahydrofuran (5 ml) was added dropwise over 10 minutes. The reaction mixture was continued to be stirred at room temperature for 5 h. Isopropanol (1 ml) was added at the termination of the reaction. The reaction mixture was poured into water and extracted with ethyl acetate (15 ml x 2). The organic phases were combined, concentrated and purified by silica gel column chromatography to afford the target product 4-methyl-2,2'-bipyridine (1.51 g, 89% yield, based on 4-methyl-2-phenylsulfonylpyridine) as a white solid. The product was characterized by 1H-NMR (CDCl3): δ 2.36 (s, 3H), 7.06 (d, 1H, J = 5.0 Hz), 7.20-7.25 (m, 1H), 7.69-7.74 (m, 1H), 8.16 (s, 1H), 8.32 (d, 1H, J = 8.0 Hz), 8.46 (d, 1H, J = 4.6 Hz) , 8.57-8.63 (m, 1H). | | References | [1] Patent: EP1548005, 2005, A1. Location in patent: Page/Page column 11 |
| | 4-Methyl-2,2'-bipyridine Preparation Products And Raw materials |
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