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| | ANTI-CD1A Basic information |
| Product Name: | ANTI-CD1A | | Synonyms: | ANTI-HUMAN CD1A, CLONE B-B5, MONOCLONAL ANTIBODY;Anti-CD1A antibody produced in rabbit;Anti-CD1a antigen antibody produced in rabbit;Anti-hTa1 thymocyte antigen antibody produced in rabbit;Anti-T-cell surface antigen T6/Leu-6 antibody produced in rabbit;Anti-T-cell surface glycoprotein CD1a precursor antibody produced in rabbit;Anti-CD1C (96-110) antibody produced in rabbit;Monoclonal Anti-CD1A antibody produced in mouse | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-CD1A Structure]() |
| | ANTI-CD1A Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous solution | | biological source | rabbit |
| Hazard Codes | Xn | | Risk Statements | 22 | | Storage Class | 10 - Combustible liquids |
| | ANTI-CD1A Usage And Synthesis |
| Uses | The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 2-8 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator. | | General Description | This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. (provided by RefSeq) | | Biological Activity | CD1 (cluster of differentiation 1) family of proteins is responsible for the capture and presentation of self and microbial glycolipids to the specific T cells. CD1A plays an important role in the host defense mechanism against microbial infection. It also facilitates early stages of immune response through CD1A-reactive T cells. This is achieved by inducing cytokine production and dendritic cell maturation, and activating cells such as NK (natural killer) cells and macrophages. The SNP rs411089, present in an intron in the CD1A gene is associated with increased susceptibility to tuberculosis, in Vietnamese population. Hence, it can be hypothesized th at CD1A plays an important role in host defense against tuberculosis. The expression of this protein is also increased in monocyte culture derived from untreated multiple sclerosis (MS) patients, as opposed to expression in monocyte culture obtained from treated MS patients. |
| | ANTI-CD1A Preparation Products And Raw materials |
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