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| | 5-METHYLINDOLE-3-CARBOXYLIC ACID METHYL ESTER Basic information |
| Product Name: | 5-METHYLINDOLE-3-CARBOXYLIC ACID METHYL ESTER | | Synonyms: | RARECHEM AL BF 0707;Methyl 5-methylindole-3-carboxylate;5-METHYLINDOLE-3-CARBOXYLIC ACID METHYL ESTER;5-METHYL-1H-INDOLE-3-CARBOXYLIC ACID METHYL ESTER;METHYL 5-METHYL-1H-INDOLE-3-CARBOXYLATE;1H-Indole-3-carboxylicacid,5-Methyl-,Methylester;5-Methylindole-3-Carbocylic acid methyl ester | | CAS: | 227960-12-5 | | MF: | C11H11NO2 | | MW: | 189.21 | | EINECS: | 607-884-2 | | Product Categories: | Indole | | Mol File: | 227960-12-5.mol |  |
| | 5-METHYLINDOLE-3-CARBOXYLIC ACID METHYL ESTER Chemical Properties |
| Boiling point | 345.1±22.0 °C(Predicted) | | density | 1.212±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 15.59±0.30(Predicted) | | Appearance | Off-white to light yellow Solid | | CAS DataBase Reference | 227960-12-5(CAS DataBase Reference) |
| | 5-METHYLINDOLE-3-CARBOXYLIC ACID METHYL ESTER Usage And Synthesis |
| Synthesis | GENERAL PROCEDURE: Following the above procedure, the crude reaction mixture was diluted with methanol (MeOH) and cooled to 0 °C. Sulfoxide chloride (SOCl2, 36 μL, 0.5 mmol) was then slowly added and the reaction was stirred at room temperature for 3 hours. Upon completion of the reaction, additional methanol (MeOH) was added and the reaction mixture was heated to reflux for 6 hours. At the end of the reaction, the reaction was quenched with deionized water (H2O) and extracted with ethyl acetate (EtOAc, 3 times). All organic layers were combined and dried with anhydrous magnesium sulfate (MgSO4) and subsequently concentrated under reduced pressure. Finally, the crude product was purified by preparative thin layer chromatography (TLC, unfolding reagent ratio petroleum ether: ethyl acetate = 7:3) to afford the target compounds, methyl 5-methylindole-3-carboxylate (5a-b). | | References | [1] Heterocycles, 2015, vol. 90, # 2, p. 1196 - 1204 |
| | 5-METHYLINDOLE-3-CARBOXYLIC ACID METHYL ESTER Preparation Products And Raw materials |
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