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(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride

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(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride manufacturers
(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride Basic information
Product Name:(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride
Synonyms:4-PyriMidineethanol, 6-chloro-a-(2,4-difluorophenyl)-5-fluoro-b-Methyl-a-(1H-1,2,4-triazol-1-ylMethyl)-;(2R,3S/2S,3R)-3-(4-CHLORO-5-FLUORO PYRIMIDIN-6-YL)-2-(2,4-DIFLUOROPHENYL)-1-(1H-1,2,4-TRIAZOL-1-YL);Voriconazole (RR,SS)-6-Chloro IMpurity;(2S,3R)-3-(6-chloro-5-fluoropyriMidin-4-yl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride;6-Chloro Voriconazole;Voriconazole (RS,SR)-6-Chloro Impurity;(2R,3S/2S,3R)-3-(4-CHLORO-5-FLUORO-6-PYRIMIDINYL)-2-(2,4-DIFLUOROPHENYL)-1-(1H-1,2,4-TRIAZOL-1-YL)-2-BUTANOL HCL;(2R,3S/2S,3R)-3-(4-CHLORO-5-FLUORO-6-PYRIMIDINYL)-2-(2,4-DIFLUOROPHENYL)-1-(1H-1,2,4-TRIAZOL-1-YL)-2-BUTANOL HYDROCHLORIDE
CAS:188416-35-5
MF:C16H13ClF3N5O
MW:383.76
EINECS:606-140-4
Product Categories:Heterocycles;Intermediates;Intermediates & Fine Chemicals;Pharmaceuticals;INTERMEDIATESOFVORICONAZOLE
Mol File:188416-35-5.mol
(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride Structure
(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride Chemical Properties
Melting point 183-187°C
Boiling point 529.9±60.0 °C(Predicted)
density 1.51
storage temp. Refrigerator
solubility DMSO (Slightly), Methanol (Slightly)
pka11.44±0.29(Predicted)
form Solid
color Off-White
InChIInChI=1S/C16H13ClF3N5O/c1-9(14-13(20)15(17)23-7-22-14)16(26,5-25-8-21-6-24-25)11-3-2-10(18)4-12(11)19/h2-4,6-9,26H,5H2,1H3
InChIKeyBQDLXFABVRRDFU-UHFFFAOYSA-N
SMILESC(O)(CN1C=NC=N1)(C(C)C1N=CN=C(Cl)C=1F)C1C=CC(F)=CC=1F
CAS DataBase Reference188416-35-5(CAS DataBase Reference)
Safety Information
MSDS Information
(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride Usage And Synthesis
Chemical PropertiesOff-White Solid
UsesAn achiral intermediate of Voriconazole (V760000).
(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride Preparation Products And Raw materials
Preparation Products2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone-->(2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol-->Voriconazole
Tag:(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride(188416-35-5) Related Product Information
Fluorocytosine Uracil Silver sulfadiazine Cytosine Triphenylphosphine 2-Phenylphenol Sulfadiazine (Formylmethylene)triphenylphosphorane Voriconazole 4-Chloro-6-ethyl-5-fluoropyrimidine (trans)-6-Chloro-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol 4-Ethyl-5-fluoropyrimidine 6-(1-Bromoethyl)-4-chloro-5-fluoropyrimidine Voriconazole Impurity 53 1,2,4-Triazole 2-Chloro-2',4'-difluoroacetophenone Pyrimidine, 4-bromo-6-(1-bromoethyl)-5-fluoro- (2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol