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021-67680335 13052188602 |
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| | DEATH RECEPTOR 4 Basic information |
| Product Name: | DEATH RECEPTOR 4 | | Synonyms: | HUMAN TNFRSF10A;DR4;DEATH RECEPTOR 4;HUMAN STRAIL RECEPTOR-1;HUMAN SOLUBLE TRAIL RECEPTOR-1;HUMAN DR4;HUMAN APO2;STRAIL RECEPTOR-1 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![DEATH RECEPTOR 4 Structure]() |
| | DEATH RECEPTOR 4 Chemical Properties |
| storage temp. | -20°C | | form | lyophilized | | color | white | | biological source | human |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | DEATH RECEPTOR 4 Usage And Synthesis |
| Uses | Soluble tumor necrosis factor-related apoptosis-inducing ligand-receptor 1 (sTRAIL-R1) also known as DR4, is encoded by the gene mapped to human chromosome 8p21-22. Recombinant human soluble TRAIL Receptor-1/DR4 is a 22.7kDa protein (216 amino acid residues) consisting of the TNFR homologous, cysteine rich portion of the extracellular domain. TRAIL Receptor-1/DR4 and TRAIL Receptor-2/DR5 belong to the TNFR superfamily of transmembrane proteins. TRAIL-R1 contains a cytoplasmic "death domain," which can activate the cell′s apoptotic machinery. TRAIL Receptor-1/DR4 is activated by binding to either membrane anchored or soluble TRAIL/Apo2L. | | Biological Activity | Soluble tumor necrosis factor-related apoptosis-inducing ligand-receptor 1 (sTRAIL-R1) interacts with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and stimulate cell-death signaling pathway. Mutation of the sTRAIL-R1 gene is associated with the pathogenesis of non-Hodgkinμs lymphoma (NHL). In addition, variation of TRAIL-R1 also increases the risk of susceptibility to prostate cancer (PCa) in North Indian population. |
| | DEATH RECEPTOR 4 Preparation Products And Raw materials |
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