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EO 1428 manufacturers
- EO 1428
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- $159.00
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2026-07-27
- CAS:321351-00-2
- Purity:
- Supply Ability: 10g
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| | EO 1428 Basic information |
| Product Name: | EO 1428 | | Synonyms: | p38 MAP Kinase Inhibitor VIII;p38 MAPK Inhibitor VIII;EO 1428;(2-Methylphenyl)-[4-[(2-amino-4-bromophenyl)amino]-2-chlorophenyl]methanone;Methanone, [4-[(2-amino-4-bromophenyl)amino]-2-chlorophenyl](2-methylphenyl)- | | CAS: | 321351-00-2 | | MF: | C20H16BrClN2O | | MW: | 415.71 | | EINECS: | | | Product Categories: | | | Mol File: | 321351-00-2.mol |  |
| | EO 1428 Chemical Properties |
| storage temp. | Store at +4°C | | solubility | Soluble to 100 mM in DMSO and to 50 mM in ethanol | | form | Powder | | color | yellow | | InChI | 1S/C20H16BrClN2O/c1-12-4-2-3-5-15(12)20(25)16-8-7-14(11-17(16)22)24-19-9-6-13(21)10-18(19)23/h2-11,24H,23H2,1H3 | | InChIKey | HDCLCHNAEZNGNV-UHFFFAOYSA-N | | SMILES | Brc1cc(c(cc1)Nc2cc(c(cc2)C(=O)c3c(cccc3)C)Cl)N |
| WGK Germany | WGK 1 | | Storage Class | 11 - Combustible Solids |
| | EO 1428 Usage And Synthesis |
| Uses | EO 1428 is a p38 MAP kinase inhibitor with high antiinflammatory activity. | | Definition | ChEBI: [4-(2-amino-4-bromoanilino)-2-chlorophenyl]-(2-methylphenyl)methanone is a member of benzophenones. | | Biological Activity | Selective inhibitor of p38 α and p38 β 2 that displays no activity at p38 γ , p38 δ , ERK1/2 and JNK1. Inhibits production of inflammatory cytokines including IL-8, TNF- α , IL-6, IL-1 β and IL-10 (IC 50 values are 4, 5, 17, 30 and 74 nM respectively). Displays anti-inflammatory activity in murine models of acute and chronic dermatitis. | | storage | Store at +4°C |
| | EO 1428 Preparation Products And Raw materials |
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