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| | 2,3-Dihydro-1H-Pyrrolo[3,4-C]Pyridine dihydrochloride Basic information | | Application |
| Product Name: | 2,3-Dihydro-1H-Pyrrolo[3,4-C]Pyridine dihydrochloride | | Synonyms: | 2,3-Dihydro-1H-Pyrrolo[3,4-C]Pyridine dihydrochloride;2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine 2HCl;2,3-Dihydro-1H-Pyrrolo[3,5-C]Pyridine dihydrochloride;2,3-dihydro-1H-pyrrolo[3,4-c]pyridine diHCl;2,3-Dihydro-1H-pyrrolo[3,4-c]pyridin;Dihydrochlorid;1H,2H,3H-pyrrolo[3,4-c]pyridine dihydrochloride;2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDINE HYDROCHLO | | CAS: | 6000-50-6 | | MF: | C7H9ClN2 | | MW: | 156.61 | | EINECS: | 201-525-2 | | Product Categories: | | | Mol File: | 6000-50-6.mol | ![2,3-Dihydro-1H-Pyrrolo[3,4-C]Pyridine dihydrochloride Structure](CAS2/GIF/6000-50-6.gif) |
| | 2,3-Dihydro-1H-Pyrrolo[3,4-C]Pyridine dihydrochloride Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | Appearance | Off-white to gray Solid |
| | 2,3-Dihydro-1H-Pyrrolo[3,4-C]Pyridine dihydrochloride Usage And Synthesis |
| Application | 2,3-Dihydro-1H-pyrrole[3,4-C]pyridine dihydrochloride can be used as a pharmaceutical synthesis intermediate and can be prepared from propargylamine and ethyl chloroformate through a four-step reaction. Literature reports its potential use in the preparation of an A2A receptor antagonist. | | Synthesis | a. Propargylamine reacts with ethyl chloroformate to give ethyl N-propargylcarbamate.
b. The product from step a reacts with 2-chloromethylpyrimidine to yield 2-(N-ethoxycarbonyl-N-propargylaminomethyl)pyrimidine.
c. The product from step b undergoes cyclization by refluxing in xylene to give ethyl 5,7-dihydro-6H-pyrrolo[3,4-b]pyridine-6-carboxylate.
d. The ester from step c is hydrolyzed/decarboxylated in conc. HCl to yield 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine dihydrochloride. |
| | 2,3-Dihydro-1H-Pyrrolo[3,4-C]Pyridine dihydrochloride Preparation Products And Raw materials |
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