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2,3-Dihydro-1H-Pyrrolo[3,4-C]Pyridine dihydrochloride

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2,3-Dihydro-1H-Pyrrolo[3,4-C]Pyridine dihydrochloride manufacturers
2,3-Dihydro-1H-Pyrrolo[3,4-C]Pyridine dihydrochloride Basic information
Application
Product Name:2,3-Dihydro-1H-Pyrrolo[3,4-C]Pyridine dihydrochloride
Synonyms:2,3-Dihydro-1H-Pyrrolo[3,4-C]Pyridine dihydrochloride;2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine 2HCl;2,3-Dihydro-1H-Pyrrolo[3,5-C]Pyridine dihydrochloride;2,3-dihydro-1H-pyrrolo[3,4-c]pyridine diHCl;2,3-Dihydro-1H-pyrrolo[3,4-c]pyridin;Dihydrochlorid;1H,2H,3H-pyrrolo[3,4-c]pyridine dihydrochloride;2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDINE HYDROCHLO
CAS:6000-50-6
MF:C7H9ClN2
MW:156.61
EINECS:201-525-2
Product Categories:
Mol File:6000-50-6.mol
2,3-Dihydro-1H-Pyrrolo[3,4-C]Pyridine dihydrochloride Structure
2,3-Dihydro-1H-Pyrrolo[3,4-C]Pyridine dihydrochloride Chemical Properties
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
AppearanceOff-white to gray Solid
Safety Information
HS Code 2933399990
MSDS Information
2,3-Dihydro-1H-Pyrrolo[3,4-C]Pyridine dihydrochloride Usage And Synthesis
Application2,3-Dihydro-1H-pyrrole[3,4-C]pyridine dihydrochloride can be used as a pharmaceutical synthesis intermediate and can be prepared from propargylamine and ethyl chloroformate through a four-step reaction. Literature reports its potential use in the preparation of an A2A receptor antagonist.
Synthesisa. Propargylamine reacts with ethyl chloroformate to give ethyl N-propargylcarbamate.
b. The product from step a reacts with 2-chloromethylpyrimidine to yield 2-(N-ethoxycarbonyl-N-propargylaminomethyl)pyrimidine.
c. The product from step b undergoes cyclization by refluxing in xylene to give ethyl 5,7-dihydro-6H-pyrrolo[3,4-b]pyridine-6-carboxylate.
d. The ester from step c is hydrolyzed/decarboxylated in conc. HCl to yield 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine dihydrochloride.
2,3-Dihydro-1H-Pyrrolo[3,4-C]Pyridine dihydrochloride Preparation Products And Raw materials
Tag:2,3-Dihydro-1H-Pyrrolo[3,4-C]Pyridine dihydrochloride(6000-50-6) Related Product Information
2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine 2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine hydrochloride 2-Benzyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine 2H-Pyrrolo[3,4-c]pyridine-2-carboxylic acid, 1,3-dihydro-, 1,1-dimethylethyl ester 6-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine hydrochloride 1H-Pyrrolo[3,4-c]pyridine, 2,3-dihydro-6-methyl-, hydrochloride (1:1)