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A 419259 trihydrochloride

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Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:A 419259；RK-20449
CAS:364042-47-7
Purity:98.00% Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 +8613203830695
Email: laboratory@coreychem.com
Products Intro: Product Name:7-((1r,4r)-4-(4-methylpiperazin-1-yl)cyclohexyl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS:364042-47-7
Purity:85.0-99.8% Package:1ASSAYS;1USD
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Email: support@targetmol.com
Products Intro: Product Name:A 419259
CAS:364042-47-7
Package:2mg;67USD
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:A-419259
CAS:364042-47-7
Package:2mg;67USD
Company Name: Amadis Chemical Company Limited
Tel: 571-89925085
Email: sales@amadischem.com
Products Intro: Product Name:A 419259
CAS:364042-47-7
Purity:0.97 Package:mgs,gs,kgs Remarks:A913772

A 419259 trihydrochloride manufacturers

  • A-419259
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  • $67.00 / 2mg
  • 2026-04-22
  • CAS:364042-47-7
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  • Purity: 99.48%
  • Supply Ability: 10g
  • A-419259
  • A-419259 pictures
  • $67.00 / 2mg
  • 2025-06-13
  • CAS:364042-47-7
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  • Purity:
  • Supply Ability: 10g
  • A 419259
  • A 419259 pictures
  • $67.00 / 2mg
  • 2025-05-30
  • CAS:364042-47-7
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  • Supply Ability: 10g
A 419259 trihydrochloride Basic information
Product Name:A 419259 trihydrochloride
Synonyms:7-((1r,4r)-4-(4-methylpiperazin-1-yl)cyclohexyl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;A 419259 trihydrochloride;A 419259;A419259;A-419259;RK 20449;RK20449;RK-20449
CAS:364042-47-7
MF:C29H34N6O
MW:482.62
EINECS:
Product Categories:
Mol File:364042-47-7.mol
A 419259 trihydrochloride Structure
A 419259 trihydrochloride Chemical Properties
Boiling point 686.4±55.0 °C(Predicted)
density 1.29±0.1 g/cm3(Predicted)
storage temp. room temp
solubility H2O: soluble10mg/mL (clear solution)
pka8.20±0.42(Predicted)
form powder
color white to beige
Water Solubility H2O: 10mg/mL (clear solution)
InChIKeyALRMEQIQFCUAMR-KOONDFAVSA-N
SMILESCl.Cl.Cl.CN1CCN(CC1)[C@H]2CC[C@@H](CC2)n3cc(-c4ccc(Oc5ccccc5)cc4)c6c(N)ncnc36
Safety Information
WGK Germany 3
Storage Class11 - Combustible Solids
MSDS Information
A 419259 trihydrochloride Usage And Synthesis
DescriptionA-419259 is an inhibitor of Src family kinases, including Src, LCK, Lyn, and Hck (IC50s = 9, <3, <3, and 11.26 nM, respectively)., It is selective for these kinases over c-Abl (IC50 = 3,000 nM) and PKC (IC50 = >33 μM). A-419259 inhibits growth of Philadelphia chromosome-positive (Ph+) K-562 and Meg-01 myeloid leukemia cells (IC50s = 0.1-0.3 and 0.1 μM, respectively), but not Ph- TF-1 and HEL cells. It induces apoptosis in K-562 cells in a concentration-dependent manner. A-419259 (300 nM) inhibits differentiation of murine embryonic stem cells while maintaining pluripotency. It reduces the total number of acute myeloid leukemia (AML) cells, as well as AML stem cells, in the bone marrow and spleen in mouse patient-derived xenograft (PDX) models of AML when administered at a dose of 30 mg/kg twice daily.
UsesA 419259 Trihydrochloride is the hydrochloride form of A 419259 which is a Src kinase inhibitor and can be used in treatment of chronic myelogenous leukemia, lymphangioleiomyomatosis and tuberous sclerosis.
References[1] MATTHEW B WILSON. Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr–Abl signal transduction and oncogenesis[J]. Oncogene, 2002, 21 53: 8075-8088. DOI: 10.1038/sj.onc.1206008
[2] T PENE-DUMITRESCU. An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad-spectrum Src family kinase inhibitor A-419259[J]. Oncogene, 2008, 27 56: 7055-7069. DOI: 10.1038/onc.2008.330
[3] MALCOLM A MEYN. SRC family kinase activity is required for murine embryonic stem cell growth and differentiation.[J]. Molecular Pharmacology, 2005, 68 5: 1320-1330. DOI: 10.1124/mol.104.010231
[4] YORIKO SAITO. A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo[J]. Science Translational Medicine, 2013, 5 181. DOI: 10.1126/scitranslmed.3004387
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