2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺
| 中文名称 | 2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺 |
|---|---|
| 中文同义词 | NA+-CA2+EXCHANGER抑制剂(SEA0400);2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺;SEA0400游离态;2-(4-((2,5-二氟苄基)氧基)苯氧基)-5-乙氧基苯胺;化合物 SEA0400;化合物SEA0400,10 MM DMSO 溶液;223104-29-8;SEA0400;SEA0400 试剂 |
| 英文名称 | SEA-0400 |
| 英文同义词 | SEA-0400;BenzenaMine, 2-[4-[(2,5-difluorophenyl)Methoxy]phenoxy]-5-ethoxy-;2-[4-[(2,5-Difluorophenyl)methoxy]phenoxy]-5-ethoxybenzenamine;SEA 0400; SEA-0400;2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline;2-(4-((2,5-DIFLUOROBENZYL)OXY)PHENOXY)-5-ETHOXYANILINE;CS-1043;SEA 0400; SEA-0400;SEA0400 |
| CAS号 | 223104-29-8 |
| 分子式 | C21H19F2NO3 |
| 分子量 | 371.38 |
| EINECS号 | |
| 相关类别 | 抑制剂;细胞生物学试剂;膜转运/离子通道 |
| Mol文件 | 223104-29-8.mol |
| 结构式 | ![2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺 结构式](CAS/20150408/GIF/223104-29-8.gif) |
2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺 性质
| 沸点 | 485.0±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.254±0.06 g/cm3(Predicted) |
| 储存条件 | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| 溶解度 | 不溶于水； DMSO 中≥18.57 mg/mL； ≥46.4 mg/mL，乙醇溶液，超声波 |
| 形态 | 固体 |
| 酸度系数(pKa) | 4.04±0.10(Predicted) |
| 颜色 | 白色至卡其色 |
| InChI | 1S/C21H19F2NO3/c1-2-25-18-8-10-21(20(24)12-18)27-17-6-4-16(5-7-17)26-13-14-11-15(22)3-9-19(14)23/h3-12H,2,13,24H2,1H3 |
| InChIKey | YSUBLPUJDOWYDP-UHFFFAOYSA-N |
| SMILES | CCOC1=CC=C(OC2=CC=C(OCC3=C(F)C=CC(F)=C3)C=C2)C(N)=C1 |
| Target | Value |
|
p38 MAPK
() | |
|
ERK
() | |
|
ROS
() | |
|
NCX
(in cultured astrocytes) | 5.0 nM |
|
NCX
(in cultured microglia) | 8.3 nM |
SEA0400 inhibits Na + -dependent 45 Ca 2+ uptake in cultured neurons, astrocytes, and microglia. IC 50 values of SEA0400 are 33 nM (neurons), 5.0 nM (astrocytes), and 8.3 nM (microglia). SEA0400 prevents sodium nitroprusside (SNP) to increase ERK and p38 MAPK phosphorylation, and production of reactive oxygen species (ROS) in an extracellular Ca 2+ -dependent manner.
SEA0400 (3 mg/kg + 3 mg/kg/h for 2 h, i.v.) attenuates the infarct volume in the cerebral cortex and striatum, does not affect the mean the regional cortical blood flow in anesthetized rats. SEA0400 protects against the dopaminergic neurotoxicity (determined by dopamine levels in the midbrain and striatum, tyrosine hydroxylase immunoreactivity in the substantia nigra and striatum, striatal dopamine release, and motor deficits) in MPTP-treated C57BL/6J mice.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/07/06 | S6920 | 2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺 SEA0400 | 223104-29-8 | 5mg | 2425.95元 |
| 2026/07/06 | S6920 | 2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺 SEA0400 | 223104-29-8 | 25mg | 7425.69元 |